Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia

Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia

Copyright © 2019 American Society for Microbiology. All Rights Reserved. Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (medi...

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Main Authors: Taniya Paiboonvong, Wichit Nosoongnoen, Korbtham Sathirakul, Viratch Tangsujaritvijit, Jaipak Kaemapairoj, Pramote Tragulpiankit, Preecha Montakantikul
Other Authors: Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Format: Article
Published: 2020
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/52172
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spelling th-mahidol.521722020-01-27T17:24:48Z Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia Taniya Paiboonvong Wichit Nosoongnoen Korbtham Sathirakul Viratch Tangsujaritvijit Jaipak Kaemapairoj Pramote Tragulpiankit Preecha Montakantikul Faculty of Medicine, Ramathibodi Hospital, Mahidol University Mahidol University Medicine Copyright © 2019 American Society for Microbiology. All Rights Reserved. Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.) 2020-01-27T10:24:48Z 2020-01-27T10:24:48Z 2019-01-01 Article Antimicrobial Agents and Chemotherapy. Vol.63, No.10 (2019) 10.1128/AAC.00800-19 10986596 00664804 2-s2.0-85072588748 https://repository.li.mahidol.ac.th/handle/123456789/52172 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072588748&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Taniya Paiboonvong
Wichit Nosoongnoen
Korbtham Sathirakul
Viratch Tangsujaritvijit
Jaipak Kaemapairoj
Pramote Tragulpiankit
Preecha Montakantikul
Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
description Copyright © 2019 American Society for Microbiology. All Rights Reserved. Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.)
author2 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
author_facet Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Taniya Paiboonvong
Wichit Nosoongnoen
Korbtham Sathirakul
Viratch Tangsujaritvijit
Jaipak Kaemapairoj
Pramote Tragulpiankit
Preecha Montakantikul
format Article
author Taniya Paiboonvong
Wichit Nosoongnoen
Korbtham Sathirakul
Viratch Tangsujaritvijit
Jaipak Kaemapairoj
Pramote Tragulpiankit
Preecha Montakantikul
author_sort Taniya Paiboonvong
title Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
title_short Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
title_full Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
title_fullStr Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
title_full_unstemmed Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia
title_sort pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill thai patients with pneumonia
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/52172
_version_ 1763494377769926656

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