Stability evaluations on Thunbergia laurifolia Lindl. leaf extract through HPLC, TLC and free radical scavenging activity analysis
The 1st Pharmaceutical Sciences Asia Conference 2019 Theme : Pharmaceutical Sciences toward Health Innovation in the Disruptive Era. Bangkok Midtown Hotel, Thailand. August 22, 2019, page 40-44
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2020
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th-mahidol.523892023-03-30T12:02:12Z Stability evaluations on Thunbergia laurifolia Lindl. leaf extract through HPLC, TLC and free radical scavenging activity analysis Chaweewan Suwanvecho Pongtip Sithisarn Supavadee Timum Nidthida Archeepsudjarit Piyanuch Rojsanga ปิยนุช โรจน์สง่า Mahidol University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry Mahidol University. Faculty of Pharmacy. Department of Pharmacognosy Mahidol University. Faculty of Pharmacy. Center of Analysis for Product Quality (Chemical division) Thunbergia laurifolia Stability test Caffeic acid Rosmarinic acid DPPH The 1st Pharmaceutical Sciences Asia Conference 2019 Theme : Pharmaceutical Sciences toward Health Innovation in the Disruptive Era. Bangkok Midtown Hotel, Thailand. August 22, 2019, page 40-44 Regulatory guidelines recommend efficient stability studies on herbal products to establish their shelf lifes. In this study, dried extracts of Thunbergia laurifolia Lindl. leaves were subjected to three different storage conditions for six months: 1) 30 ± 2 ºC, 75 ± 5 % relative humidity (RH), 2) 40 ± 2 ºC, 75 ± 5 %RH, and 3) 2-8 ºC. Control and stability tested samples were evaluated for physical appearance, moisture content, caffeic acid and rosmarinic acid contents as chemical markers, and thin layer chromatography fingerprints, and determination for DPPH scavenging activity. Chemical marker contents and DPPH scavenging activities of the stability tested samples comparably retained with respect to the control samples after the storage for 3 months in all storage conditions. Pearson correlation analysis revealed the strong positive correlation between antioxidant activity and rosmarinic acid content of stability samples stored after 6 months with correlation coefficient (r) values more than 0.901 However, antioxidant activity was correlated positively with the caffeic acid content only stored after 3 months (r values less than 0.742). The results suggested that rosmarinic acid is more suitable to use as a chemical marker for evaluation of chemical and biological shelf lives of T. laurifolia leaf products. 2020-01-28T03:33:55Z 2020-01-28T03:33:55Z 2020-01-28 2019 Proceeding Article https://repository.li.mahidol.ac.th/handle/123456789/52389 eng Mahidol University Faculty of Pharmacy Mahidol University application/pdf |
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English |
| topic |
Thunbergia laurifolia Stability test Caffeic acid Rosmarinic acid DPPH |
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Thunbergia laurifolia Stability test Caffeic acid Rosmarinic acid DPPH Chaweewan Suwanvecho Pongtip Sithisarn Supavadee Timum Nidthida Archeepsudjarit Piyanuch Rojsanga ปิยนุช โรจน์สง่า Stability evaluations on Thunbergia laurifolia Lindl. leaf extract through HPLC, TLC and free radical scavenging activity analysis |
| description |
The 1st Pharmaceutical Sciences Asia Conference 2019 Theme : Pharmaceutical Sciences toward Health Innovation in the Disruptive Era. Bangkok Midtown Hotel, Thailand. August 22, 2019, page 40-44 |
| author2 |
Mahidol University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry |
| author_facet |
Mahidol University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry Chaweewan Suwanvecho Pongtip Sithisarn Supavadee Timum Nidthida Archeepsudjarit Piyanuch Rojsanga ปิยนุช โรจน์สง่า |
| format |
Proceeding Article |
| author |
Chaweewan Suwanvecho Pongtip Sithisarn Supavadee Timum Nidthida Archeepsudjarit Piyanuch Rojsanga ปิยนุช โรจน์สง่า |
| author_sort |
Chaweewan Suwanvecho |
| title |
Stability evaluations on Thunbergia laurifolia Lindl. leaf extract through HPLC, TLC and free radical scavenging activity analysis |
| title_short |
Stability evaluations on Thunbergia laurifolia Lindl. leaf extract through HPLC, TLC and free radical scavenging activity analysis |
| title_full |
Stability evaluations on Thunbergia laurifolia Lindl. leaf extract through HPLC, TLC and free radical scavenging activity analysis |
| title_fullStr |
Stability evaluations on Thunbergia laurifolia Lindl. leaf extract through HPLC, TLC and free radical scavenging activity analysis |
| title_full_unstemmed |
Stability evaluations on Thunbergia laurifolia Lindl. leaf extract through HPLC, TLC and free radical scavenging activity analysis |
| title_sort |
stability evaluations on thunbergia laurifolia lindl. leaf extract through hplc, tlc and free radical scavenging activity analysis |
| publishDate |
2020 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/52389 |
| _version_ |
1763493957550997504 |