Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper

Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were is...

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Main Authors:	Apisada Jiso, Siriporn Kittiwisut, Ruttanaporn Chantakul, Supreeya Yuenyongsawad, Sumaitt Putchakarn, Till F. Schäberle, Prapapan Temkitthaworn, Kornkanok Ingkaninan, Kulathida Chaithirayanon, Anuchit Plubrukarn
Other Authors:	Walailak University
Format:	Article
Published:	2020
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/53582
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Institution:	Mahidol University

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spelling	th-mahidol.535822020-03-26T12:12:24Z Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper Apisada Jiso Siriporn Kittiwisut Ruttanaporn Chantakul Supreeya Yuenyongsawad Sumaitt Putchakarn Till F. Schäberle Prapapan Temkitthaworn Kornkanok Ingkaninan Kulathida Chaithirayanon Anuchit Plubrukarn Walailak University Naresuan University Justus Liebig University Giessen Mahidol University Thammasat University Burapha University Prince of Songkla University Fraunhofer Institute for Molecular Biology and Applied Ecology IME Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were isolated and reported here for the first time. Particularly, compound 2 is the first member of merosesquiterpenes with a polyketide side chain substituted on C-19. All of the isolated compounds were examined for steroid 5α-reductase inhibitory activity. Cyclospongiaquinone 1 (5) showed a strong activity in the same range as that of standard finasteride. 2020-03-26T04:30:57Z 2020-03-26T04:30:57Z 2020-02-28 Article Journal of Natural Products. Vol.83, No.2 (2020), 532-536 10.1021/acs.jnatprod.9b00886 15206025 01633864 2-s2.0-85079751529 https://repository.li.mahidol.ac.th/handle/123456789/53582 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079751529&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Apisada Jiso Siriporn Kittiwisut Ruttanaporn Chantakul Supreeya Yuenyongsawad Sumaitt Putchakarn Till F. Schäberle Prapapan Temkitthaworn Kornkanok Ingkaninan Kulathida Chaithirayanon Anuchit Plubrukarn Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
description	Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were isolated and reported here for the first time. Particularly, compound 2 is the first member of merosesquiterpenes with a polyketide side chain substituted on C-19. All of the isolated compounds were examined for steroid 5α-reductase inhibitory activity. Cyclospongiaquinone 1 (5) showed a strong activity in the same range as that of standard finasteride.
author2	Walailak University
author_facet	Walailak University Apisada Jiso Siriporn Kittiwisut Ruttanaporn Chantakul Supreeya Yuenyongsawad Sumaitt Putchakarn Till F. Schäberle Prapapan Temkitthaworn Kornkanok Ingkaninan Kulathida Chaithirayanon Anuchit Plubrukarn
format	Article
author	Apisada Jiso Siriporn Kittiwisut Ruttanaporn Chantakul Supreeya Yuenyongsawad Sumaitt Putchakarn Till F. Schäberle Prapapan Temkitthaworn Kornkanok Ingkaninan Kulathida Chaithirayanon Anuchit Plubrukarn
author_sort	Apisada Jiso
title	Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
title_short	Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
title_full	Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
title_fullStr	Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
title_full_unstemmed	Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
title_sort	quintaquinone, a merosesquiterpene from the yellow sponge verongula cf. rigida esper
publishDate	2020
url	https://repository.li.mahidol.ac.th/handle/123456789/53582
_version_	1763496528051175424

Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper

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