Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were is...
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th-mahidol.535822020-03-26T12:12:24Z Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper Apisada Jiso Siriporn Kittiwisut Ruttanaporn Chantakul Supreeya Yuenyongsawad Sumaitt Putchakarn Till F. Schäberle Prapapan Temkitthaworn Kornkanok Ingkaninan Kulathida Chaithirayanon Anuchit Plubrukarn Walailak University Naresuan University Justus Liebig University Giessen Mahidol University Thammasat University Burapha University Prince of Songkla University Fraunhofer Institute for Molecular Biology and Applied Ecology IME Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were isolated and reported here for the first time. Particularly, compound 2 is the first member of merosesquiterpenes with a polyketide side chain substituted on C-19. All of the isolated compounds were examined for steroid 5α-reductase inhibitory activity. Cyclospongiaquinone 1 (5) showed a strong activity in the same range as that of standard finasteride. 2020-03-26T04:30:57Z 2020-03-26T04:30:57Z 2020-02-28 Article Journal of Natural Products. Vol.83, No.2 (2020), 532-536 10.1021/acs.jnatprod.9b00886 15206025 01633864 2-s2.0-85079751529 https://repository.li.mahidol.ac.th/handle/123456789/53582 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079751529&origin=inward |
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Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Apisada Jiso Siriporn Kittiwisut Ruttanaporn Chantakul Supreeya Yuenyongsawad Sumaitt Putchakarn Till F. Schäberle Prapapan Temkitthaworn Kornkanok Ingkaninan Kulathida Chaithirayanon Anuchit Plubrukarn Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper |
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Copyright © 2020 American Chemical Society and American Society of Pharmacognosy. A chemical investigation of the sponge Verongula cf. rigida led to the isolation of 13 merosesquiterpenes, among which quintaquinone (2), 5-epi-nakijiquinone L (3), and 3-farnesyl-2-hydroxy-5-methoxyquinone (4) were isolated and reported here for the first time. Particularly, compound 2 is the first member of merosesquiterpenes with a polyketide side chain substituted on C-19. All of the isolated compounds were examined for steroid 5α-reductase inhibitory activity. Cyclospongiaquinone 1 (5) showed a strong activity in the same range as that of standard finasteride. |
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Walailak University |
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Walailak University Apisada Jiso Siriporn Kittiwisut Ruttanaporn Chantakul Supreeya Yuenyongsawad Sumaitt Putchakarn Till F. Schäberle Prapapan Temkitthaworn Kornkanok Ingkaninan Kulathida Chaithirayanon Anuchit Plubrukarn |
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Article |
author |
Apisada Jiso Siriporn Kittiwisut Ruttanaporn Chantakul Supreeya Yuenyongsawad Sumaitt Putchakarn Till F. Schäberle Prapapan Temkitthaworn Kornkanok Ingkaninan Kulathida Chaithirayanon Anuchit Plubrukarn |
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Apisada Jiso |
title |
Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper |
title_short |
Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper |
title_full |
Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper |
title_fullStr |
Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper |
title_full_unstemmed |
Quintaquinone, a Merosesquiterpene from the Yellow Sponge Verongula cf. rigida Esper |
title_sort |
quintaquinone, a merosesquiterpene from the yellow sponge verongula cf. rigida esper |
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2020 |
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https://repository.li.mahidol.ac.th/handle/123456789/53582 |
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1763496528051175424 |