Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data

• Main Authors: Xin Hui S. Chan, Yan Naung Win, Ilsa L. Haeusler, Jireh Y. Tan, Shanghavie Loganathan, Sompob Saralamba, Shu Kiat S. Chan, Elizabeth A. Ashley, Karen I. Barnes, Rita Baiden, Peter U. Bassi, Abdoulaye Djimde, Grant Dorsey, Stephan Duparc, Borimas Hanboonkunupakarn, Feiko O. Ter Kuile, Marcus V.G. Lacerda, Amit Nasa, François H. Nosten, Cyprian O. Onyeji, Sasithon Pukrittayakamee, André M. Siqueira, Joel Tarning, Walter R.J. Taylor, Giovanni Valentini, Michèle van Vugt, David Wesche, Nicholas P.J. Day, Christopher L.H. Huang, Josep Brugada, Ric N. Price, Nicholas J. White
• Other Authors: Certara USA, Inc.
• Format: Article
• Published: 2020
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/53749
• Institution: Mahidol University

BACKGROUND: Electrocardiographic QT interval prolongation is the most widely used risk marker for ventricular arrhythmia potential and thus an important component of drug cardiotoxicity assessments. Several antimalarial medicines are associated with QT interval prolongation. However, interpretation...