Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support among Patients with Septic Shock: The VITAMINS Randomized Clinical Trial

• Main Authors: Tomoko Fujii, Nora Luethi, Paul J. Young, Daniel R. Frei, Glenn M. Eastwood, Craig J. French, Adam M. Deane, Yahya Shehabi, Ludhmila A. Hajjar, Gisele Oliveira, Andrew A. Udy, Neil Orford, Samantha J. Edney, Anna L. Hunt, Harriet L. Judd, Laurent Bitker, Luca Cioccari, Thummaporn Naorungroj, Fumitaka Yanase, Samantha Bates, Forbes McGain, Elizabeth P. Hudson, Wisam Al-Bassam, Dhiraj Bhatia Dwivedi, Chloe Peppin, Phoebe McCracken, Judit Orosz, Michael Bailey, Rinaldo Bellomo
• Other Authors: Graduate School of Medicine
• Format: Conference or Workshop Item
• Published: 2020
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/53761
• Institution: Mahidol University

© 2020 American Medical Association. All rights reserved. Importance: It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock. Objective: To determine whether the combination of vitamin C, hydrocortisone, and...