Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin
© 2020 Elsevier B.V. This study reports for the first time the fabrication of highly porous aerogels of mixed gum tragacanth-polyvinyl alcohol (GT-PVA) for loading and oral delivery of silymarin (SM). Various analytical techniques were used to investigate changes in the physical, textural, mechanica...
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th-mahidol.544552020-05-05T12:20:30Z Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin Nushin Niknia Rassoul Kadkhodaee Mohammad Naghi Eshtiaghi Research Institute of Food Science and Technology, Mashhad Mahidol University Biochemistry, Genetics and Molecular Biology Economics, Econometrics and Finance Energy © 2020 Elsevier B.V. This study reports for the first time the fabrication of highly porous aerogels of mixed gum tragacanth-polyvinyl alcohol (GT-PVA) for loading and oral delivery of silymarin (SM). Various analytical techniques were used to investigate changes in the physical, textural, mechanical and microstructural properties of aerogels as affected by blending ratio and vacuum impregnation (VI) of SM. Results showed that the mixing ratio of 1:1 led to aerogels of larger surface area (1029.20 m2·g−1) and superior physicochemical properties. However, at mixing ratio of 3:1 (GT:PVA) higher loading capacity (45.57% ± 2.3%) was obtained. SM loading, on the other hand, had an adverse effect on the porosity, microstructure and physical attributes of aerogels transforming them from meso-porous to macro-porous structures. The release rate of SM in simulated gastrointestinal media was found to follow Korsmeyere-Peppas model. 2020-05-05T05:00:57Z 2020-05-05T05:00:57Z 2020-08-15 Article International Journal of Biological Macromolecules. Vol.157, (2020), 151-157 10.1016/j.ijbiomac.2020.04.202 18790003 01418130 2-s2.0-85083839342 https://repository.li.mahidol.ac.th/handle/123456789/54455 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85083839342&origin=inward |
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Biochemistry, Genetics and Molecular Biology Economics, Econometrics and Finance Energy Nushin Niknia Rassoul Kadkhodaee Mohammad Naghi Eshtiaghi Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin |
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© 2020 Elsevier B.V. This study reports for the first time the fabrication of highly porous aerogels of mixed gum tragacanth-polyvinyl alcohol (GT-PVA) for loading and oral delivery of silymarin (SM). Various analytical techniques were used to investigate changes in the physical, textural, mechanical and microstructural properties of aerogels as affected by blending ratio and vacuum impregnation (VI) of SM. Results showed that the mixing ratio of 1:1 led to aerogels of larger surface area (1029.20 m2·g−1) and superior physicochemical properties. However, at mixing ratio of 3:1 (GT:PVA) higher loading capacity (45.57% ± 2.3%) was obtained. SM loading, on the other hand, had an adverse effect on the porosity, microstructure and physical attributes of aerogels transforming them from meso-porous to macro-porous structures. The release rate of SM in simulated gastrointestinal media was found to follow Korsmeyere-Peppas model. |
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Research Institute of Food Science and Technology, Mashhad |
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Research Institute of Food Science and Technology, Mashhad Nushin Niknia Rassoul Kadkhodaee Mohammad Naghi Eshtiaghi |
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Article |
author |
Nushin Niknia Rassoul Kadkhodaee Mohammad Naghi Eshtiaghi |
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Nushin Niknia |
title |
Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin |
title_short |
Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin |
title_full |
Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin |
title_fullStr |
Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin |
title_full_unstemmed |
Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin |
title_sort |
gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin |
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2020 |
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https://repository.li.mahidol.ac.th/handle/123456789/54455 |
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1763498115486187520 |