The effect of polar headgroups and spacer length on the DNA transfection of cholesterol-based cationic lipids

• Main Authors: Widchaya Radchatawedchakoon, Chopaka Thongbamrer, Wuttiphong Konbamrung, Phakamas Khattawee, Uthai Sakee, Wanlapa Roobsoong, Jetsumon Sattabongkot, Praneet Opanasopit, Boon Ek Yingyongnarongkul
• Other Authors: Ramkhamhaeng University
• Format: Article
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/54473
• Institution: Mahidol University

This journal is © The Royal Society of Chemistry. This article is related to the effects of the headgroups and spacer length of cationic lipids on transfection efficiency. To develop highly potent cationic lipids, a series of divalent lysine-diamine conjugated cholesterol-based cationic lipids with...