Efficacy of Swept-source Optical Coherence Tomography in Axial Length Measurement for Advanced Cataract Patients

SIGNIFICANCE: A major limitation of standard time-domain optical coherence tomography-based biometers (TD-OCT) is an inability to measure the axial length (AL) in advanced cataract. A new device that uses swept-source optical coherence tomography (SS-OCT) allows better light penetration. Hence, a co...

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Main Authors: Chareenun Chirapapaisan, Sabong Srivannaboon, Pratuangsri Chonpimai
Other Authors: Faculty of Medicine, Siriraj Hospital, Mahidol University
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Published: 2020
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/56196
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spelling th-mahidol.561962020-06-02T12:05:20Z Efficacy of Swept-source Optical Coherence Tomography in Axial Length Measurement for Advanced Cataract Patients Chareenun Chirapapaisan Sabong Srivannaboon Pratuangsri Chonpimai Faculty of Medicine, Siriraj Hospital, Mahidol University Health Professions Medicine SIGNIFICANCE: A major limitation of standard time-domain optical coherence tomography-based biometers (TD-OCT) is an inability to measure the axial length (AL) in advanced cataract. A new device that uses swept-source optical coherence tomography (SS-OCT) allows better light penetration. Hence, a considerable number of cataract patients who failed AL measurement by TD-OCT can be recovered by SS-OCT. PURPOSE: The purposes of this study were to evaluate the efficacy of an SS-OCT for AL measurement in advanced cataract patients and to identify characteristics of lens opacity that impede the AL measurement. METHODS: Advanced cataract patients who were unable to obtain AL measurement using a standard TD-OCT-based optical biometer (IOLMaster500; Carl Zeiss Meditec, Jena, Germany) were recruited in this study. The AL was remeasured using SS-OCT (IOLMaster700), followed by measurement with immersion ultrasonography (IU). The percentage of patients who achieved AL measurement by SS-OCT was recorded. The AL obtained from SS-OCT was then verified by comparing with the AL derived from IU. The cataract type of each patient was classified according to standard Lens Opacity Classification III score. The association between characteristics of cataract and successful AL measurement by SS-OCT was analyzed. RESULTS: Sixty-four eyes that failed AL measurement from TD-OCT were included. Fifty-six eyes (87.5%) were able to be measured by SS-OCT (95% confidence interval, 77.23 to 93.53%). The AL obtained by SS-OCT showed very high agreement with those derived from IU (intraclass correlation coefficient, 0.99). There was no statistically significant correlation between characteristics of lens opacity and the capability of SS-OCT for AL measurement (P > .05). However, there was a trend toward an inability to measure the AL in cataracts with a high grade of lens opacity. CONCLUSIONS: The efficacy of SS-OCT-based optical biometer was excellent. Of the patients with advanced cataract who failed the AL measurement by TD-OCT, 87.5% could be recovered by SS-OCT. However, there was no specific type of lens opacity associated with a failure of AL measurement using SS-OCT. 2020-06-02T04:41:43Z 2020-06-02T04:41:43Z 2020-03-01 Article Optometry and vision science : official publication of the American Academy of Optometry. Vol.97, No.3 (2020), 186-191 10.1097/OPX.0000000000001491 15389235 2-s2.0-85081970153 https://repository.li.mahidol.ac.th/handle/123456789/56196 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081970153&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Health Professions
Medicine
spellingShingle Health Professions
Medicine
Chareenun Chirapapaisan
Sabong Srivannaboon
Pratuangsri Chonpimai
Efficacy of Swept-source Optical Coherence Tomography in Axial Length Measurement for Advanced Cataract Patients
description SIGNIFICANCE: A major limitation of standard time-domain optical coherence tomography-based biometers (TD-OCT) is an inability to measure the axial length (AL) in advanced cataract. A new device that uses swept-source optical coherence tomography (SS-OCT) allows better light penetration. Hence, a considerable number of cataract patients who failed AL measurement by TD-OCT can be recovered by SS-OCT. PURPOSE: The purposes of this study were to evaluate the efficacy of an SS-OCT for AL measurement in advanced cataract patients and to identify characteristics of lens opacity that impede the AL measurement. METHODS: Advanced cataract patients who were unable to obtain AL measurement using a standard TD-OCT-based optical biometer (IOLMaster500; Carl Zeiss Meditec, Jena, Germany) were recruited in this study. The AL was remeasured using SS-OCT (IOLMaster700), followed by measurement with immersion ultrasonography (IU). The percentage of patients who achieved AL measurement by SS-OCT was recorded. The AL obtained from SS-OCT was then verified by comparing with the AL derived from IU. The cataract type of each patient was classified according to standard Lens Opacity Classification III score. The association between characteristics of cataract and successful AL measurement by SS-OCT was analyzed. RESULTS: Sixty-four eyes that failed AL measurement from TD-OCT were included. Fifty-six eyes (87.5%) were able to be measured by SS-OCT (95% confidence interval, 77.23 to 93.53%). The AL obtained by SS-OCT showed very high agreement with those derived from IU (intraclass correlation coefficient, 0.99). There was no statistically significant correlation between characteristics of lens opacity and the capability of SS-OCT for AL measurement (P > .05). However, there was a trend toward an inability to measure the AL in cataracts with a high grade of lens opacity. CONCLUSIONS: The efficacy of SS-OCT-based optical biometer was excellent. Of the patients with advanced cataract who failed the AL measurement by TD-OCT, 87.5% could be recovered by SS-OCT. However, there was no specific type of lens opacity associated with a failure of AL measurement using SS-OCT.
author2 Faculty of Medicine, Siriraj Hospital, Mahidol University
author_facet Faculty of Medicine, Siriraj Hospital, Mahidol University
Chareenun Chirapapaisan
Sabong Srivannaboon
Pratuangsri Chonpimai
format Article
author Chareenun Chirapapaisan
Sabong Srivannaboon
Pratuangsri Chonpimai
author_sort Chareenun Chirapapaisan
title Efficacy of Swept-source Optical Coherence Tomography in Axial Length Measurement for Advanced Cataract Patients
title_short Efficacy of Swept-source Optical Coherence Tomography in Axial Length Measurement for Advanced Cataract Patients
title_full Efficacy of Swept-source Optical Coherence Tomography in Axial Length Measurement for Advanced Cataract Patients
title_fullStr Efficacy of Swept-source Optical Coherence Tomography in Axial Length Measurement for Advanced Cataract Patients
title_full_unstemmed Efficacy of Swept-source Optical Coherence Tomography in Axial Length Measurement for Advanced Cataract Patients
title_sort efficacy of swept-source optical coherence tomography in axial length measurement for advanced cataract patients
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/56196
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