Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium
© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. The aim of this study was to investigate the possibility of chitosan and regenerated silk fibroin (CS/RSF) blended films as novel biomaterials for daily disposable therapeutic contact lenses based...
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th-mahidol.563432020-06-02T12:39:39Z Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium Rachasit Jeencham Manote Sutheerawattananonda Saowaluk Rungchang Waree Tiyaboonchai Suranaree University of Technology Naresuan University Mahidol University Pharmacology, Toxicology and Pharmaceutics © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. The aim of this study was to investigate the possibility of chitosan and regenerated silk fibroin (CS/RSF) blended films as novel biomaterials for daily disposable therapeutic contact lenses based ophthalmic drug delivery system. Diclofenac sodium (DS), a hydrophilic anti-inflammatory agent, was loaded into CS/RSF films by a soaking method. The best conditions of DS loading manifested the loading time of 2 h and pH 6.5 of drug solution. The drug loading capacity and the drug release profile could be controlled by varying the film RSF content. With increasing the film RSF content from 0 to 30%, the amount of loaded DS increased from 12 to 23 µg. Furthermore, the prolong drug released within therapeutic level was obtained with increasing the film RSF content. Consequently, a fast released characteristic within a therapeutic level up to 3 h was observed with the 100CS/0RSF film. On the other hand, the 70CS/30RSF film demonstrated a significant prolonged drug release within therapeutic level up to 11 h. In conclusion, the CS/RSF films are promising as novel biomaterials for daily disposable therapeutic contact lenses-based ophthalmic delivery. 2020-06-02T05:39:39Z 2020-06-02T05:39:39Z 2020-01-01 Article Drug Delivery. Vol.27, No.1 (2020), 782-790 10.1080/10717544.2020.1765432 15210464 10717544 2-s2.0-85084625590 https://repository.li.mahidol.ac.th/handle/123456789/56343 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85084625590&origin=inward |
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Pharmacology, Toxicology and Pharmaceutics Rachasit Jeencham Manote Sutheerawattananonda Saowaluk Rungchang Waree Tiyaboonchai Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium |
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© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. The aim of this study was to investigate the possibility of chitosan and regenerated silk fibroin (CS/RSF) blended films as novel biomaterials for daily disposable therapeutic contact lenses based ophthalmic drug delivery system. Diclofenac sodium (DS), a hydrophilic anti-inflammatory agent, was loaded into CS/RSF films by a soaking method. The best conditions of DS loading manifested the loading time of 2 h and pH 6.5 of drug solution. The drug loading capacity and the drug release profile could be controlled by varying the film RSF content. With increasing the film RSF content from 0 to 30%, the amount of loaded DS increased from 12 to 23 µg. Furthermore, the prolong drug released within therapeutic level was obtained with increasing the film RSF content. Consequently, a fast released characteristic within a therapeutic level up to 3 h was observed with the 100CS/0RSF film. On the other hand, the 70CS/30RSF film demonstrated a significant prolonged drug release within therapeutic level up to 11 h. In conclusion, the CS/RSF films are promising as novel biomaterials for daily disposable therapeutic contact lenses-based ophthalmic delivery. |
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Suranaree University of Technology |
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Suranaree University of Technology Rachasit Jeencham Manote Sutheerawattananonda Saowaluk Rungchang Waree Tiyaboonchai |
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Article |
author |
Rachasit Jeencham Manote Sutheerawattananonda Saowaluk Rungchang Waree Tiyaboonchai |
author_sort |
Rachasit Jeencham |
title |
Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium |
title_short |
Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium |
title_full |
Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium |
title_fullStr |
Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium |
title_full_unstemmed |
Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium |
title_sort |
novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium |
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2020 |
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https://repository.li.mahidol.ac.th/handle/123456789/56343 |
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1763488372255358976 |