Lanostane derivatives from the leaves and twigs of Garcinia wallichii

• Main Authors: Sasitorn Jaitheerapapkul, Chutima Kuhakarn, Sakchai Hongthong, Natthinee Anantachoke, Sariyarach Thanasansurapong, Arthit Chairoungdua, Kanoknetr Suksen, Narong Nuntasaen, Vichai Reutrakul
• Other Authors: National Park, Wildlife and Plant Conservation Department, Thailand
• Format: Article
• Published: 2020
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/57591
• Institution: Mahidol University

© 2020 Phytochemical Society of Europe Bioassay-guided purification of the n-hexane and ethyl acetate extracts of the leaves and twigs of Garcinia wallichii led to the isolation of four previously undescribed lanostane triterpenes, wallichinanes F–I (1–4), together with four known compounds, wallichinane A (5), wallichinane B (6), friedelin (7), and lupeol (8). All structures were determined by means of spectroscopic techniques as well as comparison with literature data. Some isolated compounds were evaluated for cytotoxicity against a panel of cultured mammalian cancer cell lines. Wallichinanes G and H displayed weak cytotoxicity, whereas wallichinanes A, B, and F were found to be inactive in all the tested cell lines.