Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
© 2020, The Author(s). Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating...
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th-mahidol.576682020-08-25T18:46:57Z Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence Haruka Toda Miriam Diaz-Varela Joan Segui-Barber Wanlapa Roobsoong Barbara Baro Susana Garcia-Silva Alicia Galiano Melisa Gualdrón-López Anne C.G. Almeida Marcelo A.M. Brito Gisely Cardoso de Melo Iris Aparici-Herraiz Carlos Castro-Cavadía Wuelton Marcelo Monteiro Eva Borràs Eduard Sabidó Igor C. Almeida Jakub Chojnacki Javier Martinez-Picado Maria Calvo Pilar Armengol Jaime Carmona-Fonseca Maria Fernanda Yasnot Ricardo Lauzurica Antonio Marcilla Hector Peinado Mary R. Galinski Marcus V.G. Lacerda Jetsumon Sattabongkot Carmen Fernandez-Becerra Hernando A. del Portillo Universidad de Córdoba, Monteria Barcelona Institute of Science and Technology (BIST) Instituto de Salud Global de Barcelona Fundacao de Medicina Tropical do Amazonas Universitat de Vic - Universitat Central de Catalunya (UVic-UCC) Universidad de Antioquia Universitat Pompeu Fabra Barcelona Institució Catalana de Recerca i Estudis Avançats Hospital Universitari Germans Trias i Pujol Fundacao Oswaldo Cruz Mahidol University Centro Nacional de Investigaciones Oncológicas The University of Texas at El Paso University of Valencia Universidade do Estado do Amazonas Universitat de Barcelona Fundació Institut dInvestigació en Ciències de la Salut Germans Trias i Pujol Emory University IrsiCaixa AIDS Research Institute Biochemistry, Genetics and Molecular Biology Chemistry Physics and Astronomy © 2020, The Author(s). Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen. 2020-08-25T09:00:56Z 2020-08-25T09:00:56Z 2020-12-01 Article Nature Communications. Vol.11, No.1 (2020) 10.1038/s41467-020-16337-y 20411723 2-s2.0-85085909618 https://repository.li.mahidol.ac.th/handle/123456789/57668 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085909618&origin=inward |
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Biochemistry, Genetics and Molecular Biology Chemistry Physics and Astronomy Haruka Toda Miriam Diaz-Varela Joan Segui-Barber Wanlapa Roobsoong Barbara Baro Susana Garcia-Silva Alicia Galiano Melisa Gualdrón-López Anne C.G. Almeida Marcelo A.M. Brito Gisely Cardoso de Melo Iris Aparici-Herraiz Carlos Castro-Cavadía Wuelton Marcelo Monteiro Eva Borràs Eduard Sabidó Igor C. Almeida Jakub Chojnacki Javier Martinez-Picado Maria Calvo Pilar Armengol Jaime Carmona-Fonseca Maria Fernanda Yasnot Ricardo Lauzurica Antonio Marcilla Hector Peinado Mary R. Galinski Marcus V.G. Lacerda Jetsumon Sattabongkot Carmen Fernandez-Becerra Hernando A. del Portillo Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
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© 2020, The Author(s). Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen. |
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Universidad de Córdoba, Monteria |
author_facet |
Universidad de Córdoba, Monteria Haruka Toda Miriam Diaz-Varela Joan Segui-Barber Wanlapa Roobsoong Barbara Baro Susana Garcia-Silva Alicia Galiano Melisa Gualdrón-López Anne C.G. Almeida Marcelo A.M. Brito Gisely Cardoso de Melo Iris Aparici-Herraiz Carlos Castro-Cavadía Wuelton Marcelo Monteiro Eva Borràs Eduard Sabidó Igor C. Almeida Jakub Chojnacki Javier Martinez-Picado Maria Calvo Pilar Armengol Jaime Carmona-Fonseca Maria Fernanda Yasnot Ricardo Lauzurica Antonio Marcilla Hector Peinado Mary R. Galinski Marcus V.G. Lacerda Jetsumon Sattabongkot Carmen Fernandez-Becerra Hernando A. del Portillo |
format |
Article |
author |
Haruka Toda Miriam Diaz-Varela Joan Segui-Barber Wanlapa Roobsoong Barbara Baro Susana Garcia-Silva Alicia Galiano Melisa Gualdrón-López Anne C.G. Almeida Marcelo A.M. Brito Gisely Cardoso de Melo Iris Aparici-Herraiz Carlos Castro-Cavadía Wuelton Marcelo Monteiro Eva Borràs Eduard Sabidó Igor C. Almeida Jakub Chojnacki Javier Martinez-Picado Maria Calvo Pilar Armengol Jaime Carmona-Fonseca Maria Fernanda Yasnot Ricardo Lauzurica Antonio Marcilla Hector Peinado Mary R. Galinski Marcus V.G. Lacerda Jetsumon Sattabongkot Carmen Fernandez-Becerra Hernando A. del Portillo |
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Haruka Toda |
title |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
title_short |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
title_full |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
title_fullStr |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
title_full_unstemmed |
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence |
title_sort |
plasma-derived extracellular vesicles from plasmodium vivax patients signal spleen fibroblasts via nf-kb facilitating parasite cytoadherence |
publishDate |
2020 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/57668 |
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1763487248327639040 |