Defective functions of HNF1A variants on BCL2L1 transactivation and beta-cell growth

• Main Authors: Jatuporn Sujjitjoon, Chutima Charoensuk, Thanita Thanyaphon, Suwattanee Kooptiwut, Prapaporn Jungtrakoon Thamtarana, Watip Tangjittipokin, Nalinee Chongjaroen, Chutima Chanprasert, Zuroida Abubakar, Sorravis Lapbenjakul, Pa thai Yenchitsomanus, Nattachet Plengvidhya
• Other Authors: Faculty of Medicine, Siriraj Hospital, Mahidol University
• Format: Article
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/57686
• Institution: Mahidol University

© 2020 Elsevier Inc. Maturity-onset diabetes of the young type 3 (MODY3) is caused by mutations in a gene encoding transcription factor hepatocyte nuclear factor 1-alpha (HNF1A). Although the roles of HNF1A in regulation of hepatic and pancreatic genes to maintain glucose homeostasis were investigat...