Protein-based, but not viral vector alone, HIV vaccine boosting drives an IgG1-biased polyfunctional humoral immune response

Protein-based, but not viral vector alone, HIV vaccine boosting drives an IgG1-biased polyfunctional humoral immune response

The RV144 HIV-1 vaccine trial results showed moderate reduction in viral infections among vaccinees as well as induction of antibody-dependent cellular cytotoxicity and vaccine-specific IgG and IgG3 responses directed at variable loop regions 1 and 2 of the HIV envelope protein. However, with the re...

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Bibliographic Details
Main Authors: Stephanie Fischinger, Sally Shin, Carolyn M. Boudreau, Margaret Ackerman, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jerome H. Kim, Merlin L. Robb, Nelson L. Michael, Robert J. O'Connell, Sandhya Vasan, Hendrik Streeck, Galit Alter
Other Authors: International Vaccine Institute, Seoul
Format: Article
Published: 2020
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/58124
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/58124

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