Stimulation of GLP-1 Receptor Inhibits Methylglyoxal-Induced Mitochondrial Dysfunctions in H9c2 Cardiomyoblasts: Potential Role of Epac/PI3K/Akt Pathway

• Main Authors: Narawat Nuamnaichati, Supachoke Mangmool, Nipon Chattipakorn, Warisara Parichatikanond
• Other Authors: Mahidol University
• Format: Article
• Published: 2020
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/58150

© Copyright © 2020 Nuamnaichati, Mangmool, Chattipakorn and Parichatikanond. Accumulation of methylglyoxal (MG) contributes to oxidative stress, apoptosis, and mitochondrial dysfunction, leading to the development of type 2 diabetes and cardiovascular diseases. Inhibition of mitochondrial abnormalit...