Initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma

© 2020 The Author(s) Although pulmonary tumor embolism (PTE) is a well-recognized end-stage form of pulmonary metastases at postmortem examination, the entity is rarely the first clinical sign of prostate cancer. Diagnosis of this condition in patients who have no previous history of malignancy is a...

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Main Authors: Tananchai Petnak, Thitiporn Suwatanapongched, Wipawi Klaisuban, Chayanin Nitiwarangkul, Prapaporn Pornsuriyasak
Other Authors: Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Format: Article
Published: 2020
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/58241
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spelling th-mahidol.582412020-08-25T18:08:18Z Initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma Tananchai Petnak Thitiporn Suwatanapongched Wipawi Klaisuban Chayanin Nitiwarangkul Prapaporn Pornsuriyasak Faculty of Medicine, Ramathibodi Hospital, Mahidol University Medicine © 2020 The Author(s) Although pulmonary tumor embolism (PTE) is a well-recognized end-stage form of pulmonary metastases at postmortem examination, the entity is rarely the first clinical sign of prostate cancer. Diagnosis of this condition in patients who have no previous history of malignancy is a challenge. Herein, we reported a 79-year-old man presented with progressive, unexplained dyspnea on exertion. Microscopic PTE coinciding with pulmonary lymphangitic carcinomatosis were readily recognized based on the presence of multifocal dilatation and beading of the peripheral pulmonary arteries with thickening of the bronchial walls and interlobular septa on the initial thin-section chest CT images. Pathologic examination of the transbronchial lung biopsy specimen revealed tumor emboli occluding both the small muscular pulmonary arteries and lymphatic vessels. These tumor cells were positive for prostatic specific antigen on immunohistochemical staining. The final diagnosis of prostatic adenocarcinoma was confirmed. Remarkable clinical and radiographic improvement was achieved following bilateral orchiectomies and anti-androgen treatment. 2020-08-25T11:08:18Z 2020-08-25T11:08:18Z 2020-01-01 Article Respiratory Medicine Case Reports. Vol.31, (2020) 10.1016/j.rmcr.2020.101163 22130071 2-s2.0-85088110400 https://repository.li.mahidol.ac.th/handle/123456789/58241 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85088110400&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Tananchai Petnak
Thitiporn Suwatanapongched
Wipawi Klaisuban
Chayanin Nitiwarangkul
Prapaporn Pornsuriyasak
Initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma
description © 2020 The Author(s) Although pulmonary tumor embolism (PTE) is a well-recognized end-stage form of pulmonary metastases at postmortem examination, the entity is rarely the first clinical sign of prostate cancer. Diagnosis of this condition in patients who have no previous history of malignancy is a challenge. Herein, we reported a 79-year-old man presented with progressive, unexplained dyspnea on exertion. Microscopic PTE coinciding with pulmonary lymphangitic carcinomatosis were readily recognized based on the presence of multifocal dilatation and beading of the peripheral pulmonary arteries with thickening of the bronchial walls and interlobular septa on the initial thin-section chest CT images. Pathologic examination of the transbronchial lung biopsy specimen revealed tumor emboli occluding both the small muscular pulmonary arteries and lymphatic vessels. These tumor cells were positive for prostatic specific antigen on immunohistochemical staining. The final diagnosis of prostatic adenocarcinoma was confirmed. Remarkable clinical and radiographic improvement was achieved following bilateral orchiectomies and anti-androgen treatment.
author2 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
author_facet Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Tananchai Petnak
Thitiporn Suwatanapongched
Wipawi Klaisuban
Chayanin Nitiwarangkul
Prapaporn Pornsuriyasak
format Article
author Tananchai Petnak
Thitiporn Suwatanapongched
Wipawi Klaisuban
Chayanin Nitiwarangkul
Prapaporn Pornsuriyasak
author_sort Tananchai Petnak
title Initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma
title_short Initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma
title_full Initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma
title_fullStr Initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma
title_full_unstemmed Initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma
title_sort initial diagnosis and successful treatment of pulmonary tumor embolism manifesting as the first clinical sign of prostatic adenocarcinoma
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/58241
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