Arylesterase activity but not PCSK9 levels is associated with chronic kidney disease in type 2 diabetes
© 2020, Springer Nature B.V. Purpose: Oxidative stress and dyslipidemia have been found to be associated with the progression of chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) patients. Paraoxonase 1 (PON-1) activity, and proprotein convertase subtilisin kexin type 9 (PCSK9) levels...
Saved in:
Main Authors: | , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2020
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/58278 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.58278 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.582782020-08-25T18:16:36Z Arylesterase activity but not PCSK9 levels is associated with chronic kidney disease in type 2 diabetes Nutsiwat Didas Witsawat Thitisopee Sureerut Porntadavity Nutjaree Jeenduang Walailak University Mahidol University Thasala Hospital Medicine © 2020, Springer Nature B.V. Purpose: Oxidative stress and dyslipidemia have been found to be associated with the progression of chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) patients. Paraoxonase 1 (PON-1) activity, and proprotein convertase subtilisin kexin type 9 (PCSK9) levels play an important role regarding anti-oxidants, and lipid metabolism, respectively. The aim of this study was to investigate the association of PON-1 activity, and PCSK9 levels with CKD in T2DM. Methods: A total of 180 T2DM (87 CKD, and 93 non-CKD) with age-, and gender-matched subjects were recruited in this study. PON-1 activity was measured with two kinds of substrate: paraoxon for paraoxonase (PONase) activity and phenylacetate for arylesterase (AREase) activity. PCSK9 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: AREase activity was significantly lower in CKD compared with non-CKD (225.53 ± 108.73 vs. 257.45 ± 106.12 kU/L, p = 0.044) in T2DM, whereas there was no significant difference in PONase activity and PCSK9 levels between CKD and non-CKD groups. In addition, multivariate logistic regression analysis showed that the lowest tertile of AREase increased the risk for CKD in T2DM (OR 3.251; 95% CI 1.333–7.926, p = 0.010), whereas PONase activity and PCSK9 levels were not associated with CKD in T2DM. Conclusion: Reduced AREase activity can increase the risk for CKD in T2DM patients. AREase activity, but not PONase activity and PCSK9 levels, may be used as the biomarker for predicting the progression of CKD in T2DM. 2020-08-25T11:16:36Z 2020-08-25T11:16:36Z 2020-01-01 Article International Urology and Nephrology. (2020) 10.1007/s11255-020-02547-2 15732584 03011623 2-s2.0-85087799455 https://repository.li.mahidol.ac.th/handle/123456789/58278 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85087799455&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Medicine |
spellingShingle |
Medicine Nutsiwat Didas Witsawat Thitisopee Sureerut Porntadavity Nutjaree Jeenduang Arylesterase activity but not PCSK9 levels is associated with chronic kidney disease in type 2 diabetes |
description |
© 2020, Springer Nature B.V. Purpose: Oxidative stress and dyslipidemia have been found to be associated with the progression of chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) patients. Paraoxonase 1 (PON-1) activity, and proprotein convertase subtilisin kexin type 9 (PCSK9) levels play an important role regarding anti-oxidants, and lipid metabolism, respectively. The aim of this study was to investigate the association of PON-1 activity, and PCSK9 levels with CKD in T2DM. Methods: A total of 180 T2DM (87 CKD, and 93 non-CKD) with age-, and gender-matched subjects were recruited in this study. PON-1 activity was measured with two kinds of substrate: paraoxon for paraoxonase (PONase) activity and phenylacetate for arylesterase (AREase) activity. PCSK9 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: AREase activity was significantly lower in CKD compared with non-CKD (225.53 ± 108.73 vs. 257.45 ± 106.12 kU/L, p = 0.044) in T2DM, whereas there was no significant difference in PONase activity and PCSK9 levels between CKD and non-CKD groups. In addition, multivariate logistic regression analysis showed that the lowest tertile of AREase increased the risk for CKD in T2DM (OR 3.251; 95% CI 1.333–7.926, p = 0.010), whereas PONase activity and PCSK9 levels were not associated with CKD in T2DM. Conclusion: Reduced AREase activity can increase the risk for CKD in T2DM patients. AREase activity, but not PONase activity and PCSK9 levels, may be used as the biomarker for predicting the progression of CKD in T2DM. |
author2 |
Walailak University |
author_facet |
Walailak University Nutsiwat Didas Witsawat Thitisopee Sureerut Porntadavity Nutjaree Jeenduang |
format |
Article |
author |
Nutsiwat Didas Witsawat Thitisopee Sureerut Porntadavity Nutjaree Jeenduang |
author_sort |
Nutsiwat Didas |
title |
Arylesterase activity but not PCSK9 levels is associated with chronic kidney disease in type 2 diabetes |
title_short |
Arylesterase activity but not PCSK9 levels is associated with chronic kidney disease in type 2 diabetes |
title_full |
Arylesterase activity but not PCSK9 levels is associated with chronic kidney disease in type 2 diabetes |
title_fullStr |
Arylesterase activity but not PCSK9 levels is associated with chronic kidney disease in type 2 diabetes |
title_full_unstemmed |
Arylesterase activity but not PCSK9 levels is associated with chronic kidney disease in type 2 diabetes |
title_sort |
arylesterase activity but not pcsk9 levels is associated with chronic kidney disease in type 2 diabetes |
publishDate |
2020 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/58278 |
_version_ |
1763493353599533056 |