Thyroid eye disease in Asians and recent advances in management
Copyright © 2020 by the Chinese Medical Association. This paper aims to review the current understanding and advances in knowledge of thyroid eye disease(TED)with a focus on Asian population. TED can significantly impact quality of life, and has devastating consequences, including facial disfigureme...
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th-mahidol.592112020-10-05T12:54:26Z Thyroid eye disease in Asians and recent advances in management Pimkwan Jaru-Ampornpan Yu Cheng Qin Jiao Raymond S. Douglas Ruijin Hospital Cedars-Sinai Medical Center Faculty of Medicine, Siriraj Hospital, Mahidol University Medicine Copyright © 2020 by the Chinese Medical Association. This paper aims to review the current understanding and advances in knowledge of thyroid eye disease(TED)with a focus on Asian population. TED can significantly impact quality of life, and has devastating consequences, including facial disfigurement and vision loss. Recent findings revealed a novel targeted therapy against TED, including teprotumumab, a human monoclonal antibody that inhibits the insulin-like growth factor-1 receptor. Teprotumumab was found to reverse the disease process in patients with active, moderate-to-severe TED. A randomized clinical trial of this drug compared to placebo showed significant improvement in clinical activity score, proptosis, subjective diplopia, and quality of life at 4 months follow-up in the treatment group. In this paper, we review the current epidemiology, pathophysiology, and advances in management of TED. 2020-10-05T05:54:26Z 2020-10-05T05:54:26Z 2020-07-25 Review Chinese Journal of Endocrinology and Metabolism. Vol.36, No.7 (2020), 541-562 10.3760/cma.j.cn311282-20200123-00039 10006699 2-s2.0-85091601863 https://repository.li.mahidol.ac.th/handle/123456789/59211 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85091601863&origin=inward |
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Medicine Pimkwan Jaru-Ampornpan Yu Cheng Qin Jiao Raymond S. Douglas Thyroid eye disease in Asians and recent advances in management |
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Copyright © 2020 by the Chinese Medical Association. This paper aims to review the current understanding and advances in knowledge of thyroid eye disease(TED)with a focus on Asian population. TED can significantly impact quality of life, and has devastating consequences, including facial disfigurement and vision loss. Recent findings revealed a novel targeted therapy against TED, including teprotumumab, a human monoclonal antibody that inhibits the insulin-like growth factor-1 receptor. Teprotumumab was found to reverse the disease process in patients with active, moderate-to-severe TED. A randomized clinical trial of this drug compared to placebo showed significant improvement in clinical activity score, proptosis, subjective diplopia, and quality of life at 4 months follow-up in the treatment group. In this paper, we review the current epidemiology, pathophysiology, and advances in management of TED. |
author2 |
Ruijin Hospital |
author_facet |
Ruijin Hospital Pimkwan Jaru-Ampornpan Yu Cheng Qin Jiao Raymond S. Douglas |
format |
Review |
author |
Pimkwan Jaru-Ampornpan Yu Cheng Qin Jiao Raymond S. Douglas |
author_sort |
Pimkwan Jaru-Ampornpan |
title |
Thyroid eye disease in Asians and recent advances in management |
title_short |
Thyroid eye disease in Asians and recent advances in management |
title_full |
Thyroid eye disease in Asians and recent advances in management |
title_fullStr |
Thyroid eye disease in Asians and recent advances in management |
title_full_unstemmed |
Thyroid eye disease in Asians and recent advances in management |
title_sort |
thyroid eye disease in asians and recent advances in management |
publishDate |
2020 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/59211 |
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1763488373353218048 |