Mitochondrial Dysfunction and Kidney Stone Disease
© Copyright © 2020 Chaiyarit and Thongboonkerd. Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone disease (nephrolithiasis/urolithiasis), particularly calcium oxalate (CaO...
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th-mahidol.598672020-11-18T16:58:00Z Mitochondrial Dysfunction and Kidney Stone Disease Sakdithep Chaiyarit Visith Thongboonkerd Faculty of Medicine, Siriraj Hospital, Mahidol University Biochemistry, Genetics and Molecular Biology Medicine © Copyright © 2020 Chaiyarit and Thongboonkerd. Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone disease (nephrolithiasis/urolithiasis), particularly calcium oxalate (CaOx; the most common type), has been shown to be associated with oxidative stress and tissue inflammation/injury. Recent evidence has demonstrated the involvement of mitochondrial dysfunction in CaOx crystal retention and aggregation as well as Randall’s plaque formation, all of which are the essential mechanisms for kidney stone formation. This review highlights the important roles of mitochondria in renal cell functions and provides the data obtained from previous investigations of mitochondria related to kidney stone disease. In addition, mechanisms for the involvement of mitochondrial dysfunction in the pathophysiology of kidney stone disease are summarized. Finally, future perspectives on the novel approach to prevent kidney stone formation by mitochondrial preservation are discussed. 2020-11-18T08:01:13Z 2020-11-18T08:01:13Z 2020-10-20 Review Frontiers in Physiology. Vol.11, (2020) 10.3389/fphys.2020.566506 1664042X 2-s2.0-85094962705 https://repository.li.mahidol.ac.th/handle/123456789/59867 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85094962705&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Sakdithep Chaiyarit Visith Thongboonkerd Mitochondrial Dysfunction and Kidney Stone Disease |
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© Copyright © 2020 Chaiyarit and Thongboonkerd. Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone disease (nephrolithiasis/urolithiasis), particularly calcium oxalate (CaOx; the most common type), has been shown to be associated with oxidative stress and tissue inflammation/injury. Recent evidence has demonstrated the involvement of mitochondrial dysfunction in CaOx crystal retention and aggregation as well as Randall’s plaque formation, all of which are the essential mechanisms for kidney stone formation. This review highlights the important roles of mitochondria in renal cell functions and provides the data obtained from previous investigations of mitochondria related to kidney stone disease. In addition, mechanisms for the involvement of mitochondrial dysfunction in the pathophysiology of kidney stone disease are summarized. Finally, future perspectives on the novel approach to prevent kidney stone formation by mitochondrial preservation are discussed. |
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Faculty of Medicine, Siriraj Hospital, Mahidol University |
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Faculty of Medicine, Siriraj Hospital, Mahidol University Sakdithep Chaiyarit Visith Thongboonkerd |
format |
Review |
author |
Sakdithep Chaiyarit Visith Thongboonkerd |
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Sakdithep Chaiyarit |
title |
Mitochondrial Dysfunction and Kidney Stone Disease |
title_short |
Mitochondrial Dysfunction and Kidney Stone Disease |
title_full |
Mitochondrial Dysfunction and Kidney Stone Disease |
title_fullStr |
Mitochondrial Dysfunction and Kidney Stone Disease |
title_full_unstemmed |
Mitochondrial Dysfunction and Kidney Stone Disease |
title_sort |
mitochondrial dysfunction and kidney stone disease |
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2020 |
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https://repository.li.mahidol.ac.th/handle/123456789/59867 |
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