Geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Worldwide, studies investigating the relationship between the lineage of Mycobacterium tuberculosis (MTB) across geographic areas has empowered the “End TB” program and understand transmission across national boundaries. Genomic diversity of...
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th-mahidol.599902020-11-18T17:03:46Z Geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area Htet Myat Win Maung Prasit Palittapongarnpim Htin Lin Aung Komwit Surachat Wint Wint Nyunt Virasakdi Chongsuvivatwong University of Otago Mahidol University Prince of Songkla University Ministry of Health and Sports National TB Programme Immunology and Microbiology Medicine © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Worldwide, studies investigating the relationship between the lineage of Mycobacterium tuberculosis (MTB) across geographic areas has empowered the “End TB” program and understand transmission across national boundaries. Genomic diversity of MTB varies with geographical locations and ethnicity. Genomic diversity can also affect the emergence of drug resistance. In Myanmar, we still have limited genetic information about geographical, ethnicity, and drug resistance linkage to MTB genetic information. This study aimed to describe the geno-spatial distribution of MTB and drug resistance profiles in Myanmar–Thailand border areas. A cross-sectional study was conducted with a total of 109 sequenced isolates. The lineages of MTB and the potential associated socio-demographic, geographic and clinical factors were analyzed using Fisher’s exact tests. p value of statistically significance was set at < 0.05. We found that 67% of the isolates were lineage 1 (L1)/East-African-Indian (EAI) (n = 73), followed by lineage 2 (L2)/Beijing (n = 26), lineage 4 (L4)/European American (n = 6) and lineage 3 (L3)/Delhi/Central Asian (n = 4). “Gender”, “type of TB patient”, “sputum smear grading” and “streptomycin resistance” were significantly different with the lineages of MTB. Sublineages of L1, which had never been reported elsewhere in Myanmar, were detected in this study area. Moreover, both ethnicity and lineage of MTB significantly differed in distribution by patient location. Diversity of the lineage of MTB and detection of new sublineages suggested that this small area had been resided by a heterogeneous population group who actively transmitted the disease. This information on distribution of lineage of MTB can be linked in the future with those on the other side of the border to evaluate cross-border transmission. 2020-11-18T09:28:50Z 2020-11-18T09:28:50Z 2020-09-30 Article Tropical Medicine and Infectious Disease. Vol.5, No.4 (2020) 10.3390/tropicalmed5040153 24146366 2-s2.0-85093522076 https://repository.li.mahidol.ac.th/handle/123456789/59990 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85093522076&origin=inward |
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Immunology and Microbiology Medicine Htet Myat Win Maung Prasit Palittapongarnpim Htin Lin Aung Komwit Surachat Wint Wint Nyunt Virasakdi Chongsuvivatwong Geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area |
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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Worldwide, studies investigating the relationship between the lineage of Mycobacterium tuberculosis (MTB) across geographic areas has empowered the “End TB” program and understand transmission across national boundaries. Genomic diversity of MTB varies with geographical locations and ethnicity. Genomic diversity can also affect the emergence of drug resistance. In Myanmar, we still have limited genetic information about geographical, ethnicity, and drug resistance linkage to MTB genetic information. This study aimed to describe the geno-spatial distribution of MTB and drug resistance profiles in Myanmar–Thailand border areas. A cross-sectional study was conducted with a total of 109 sequenced isolates. The lineages of MTB and the potential associated socio-demographic, geographic and clinical factors were analyzed using Fisher’s exact tests. p value of statistically significance was set at < 0.05. We found that 67% of the isolates were lineage 1 (L1)/East-African-Indian (EAI) (n = 73), followed by lineage 2 (L2)/Beijing (n = 26), lineage 4 (L4)/European American (n = 6) and lineage 3 (L3)/Delhi/Central Asian (n = 4). “Gender”, “type of TB patient”, “sputum smear grading” and “streptomycin resistance” were significantly different with the lineages of MTB. Sublineages of L1, which had never been reported elsewhere in Myanmar, were detected in this study area. Moreover, both ethnicity and lineage of MTB significantly differed in distribution by patient location. Diversity of the lineage of MTB and detection of new sublineages suggested that this small area had been resided by a heterogeneous population group who actively transmitted the disease. This information on distribution of lineage of MTB can be linked in the future with those on the other side of the border to evaluate cross-border transmission. |
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University of Otago |
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University of Otago Htet Myat Win Maung Prasit Palittapongarnpim Htin Lin Aung Komwit Surachat Wint Wint Nyunt Virasakdi Chongsuvivatwong |
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Article |
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Htet Myat Win Maung Prasit Palittapongarnpim Htin Lin Aung Komwit Surachat Wint Wint Nyunt Virasakdi Chongsuvivatwong |
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Htet Myat Win Maung |
title |
Geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area |
title_short |
Geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area |
title_full |
Geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area |
title_fullStr |
Geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area |
title_full_unstemmed |
Geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area |
title_sort |
geno-spatial distribution of mycobacterium tuberculosis and drug resistance profiles in myanmar⇓thai border area |
publishDate |
2020 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/59990 |
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1763495116742328320 |