Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: Female youth with perinatally acquired human immunodeficiency virus (PHIV) may be at higher risk than uni...

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Main Authors: Nittaya Phanuphak, Sirinya Teeraananchai, Rawiwan Hansudewechakul, Sivaporn Gatechompol, Kulkanya Chokephaibulkit, Hanh Le Dung Dang, Dan Ngoc Hanh Tran, Jullapong Achalapong, Nipat Teeratakulpisarn, Amphan Chalermchockcharoenkit, Manopchai Thamkhantho, Tippawan Pankam, Thida Singtoroj, Wichai Termrungruanglert, Surasith Chaithongwongwatthana, Stephen J. Kerr, Annette H. Sohn
Other Authors: Thai Red Cross Agency
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Published: 2020
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/60030
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spelling th-mahidol.600302020-11-18T16:54:52Z Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study Nittaya Phanuphak Sirinya Teeraananchai Rawiwan Hansudewechakul Sivaporn Gatechompol Kulkanya Chokephaibulkit Hanh Le Dung Dang Dan Ngoc Hanh Tran Jullapong Achalapong Nipat Teeratakulpisarn Amphan Chalermchockcharoenkit Manopchai Thamkhantho Tippawan Pankam Thida Singtoroj Wichai Termrungruanglert Surasith Chaithongwongwatthana Stephen J. Kerr Annette H. Sohn Thai Red Cross Agency Chulalongkorn University Kirby Institute Kasetsart University The HIV Netherlands Australia Thailand Research Collaboration Faculty of Medicine, Siriraj Hospital, Mahidol University Children's Hospital 1 TREAT Asia/amfAR-The Foundation for AIDS Research Chiangrai Prachanukroh Hospital Hung Vuong Hospital Medicine © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: Female youth with perinatally acquired human immunodeficiency virus (PHIV) may be at higher risk than uninfected youth for persistent anogenital human papillomavirus (HPV) infection, due to prolonged immunodeficiency. METHODS: A 3-year cohort study was conducted between 2013 and 2017 among Thai and Vietnamese PHIV and HIV-uninfected females 12-24 years, matched by age group and number of lifetime sexual partners. For HPV genotyping, cervical and anal samples were obtained at baseline and annually. Vaginal samples were collected at baseline and every 6 months. Factors associated with high-risk HPV (HR-HPV) persistence and incidence were assessed. RESULTS: We enrolled 93 PHIV and 99 HIV-uninfected females. Median age was 19 (interquartile range [IQR] 18-20) years. For the 7 HR-HPV types (16, 18, 31, 33, 45, 52, 58) in the nonavalent HPV vaccine, PHIV had significantly higher incidence (P = .03) and persistence (P = .01) than HIV-uninfected youth over a 3-year period. Having HIV (adjusted hazard ratio [aHR] 2.1, 95% confidence interval [CI] 1.1-3.9) and ever using illegal substances (aHR 4.8, 95% CI 1.8-13.0) were associated with incident 7 HR-HPV infections. HIV-positive status (adjusted prevalence ratio [aPR] 2.2, 95% CI 1.5-3.2), recent alcohol use (aPR 1.75, 95% CI 1.2-2.5), and higher number of lifetime partners (aPR 2.0, 95% CI 1.4-3.1, for 3-5 partners; aPR 1.93, 95% CI 1.2-3.2, for ≥6 partners) were significantly associated with persistent 7 HR-HPV infections. CONCLUSIONS: Female PHIV were at higher risk of having anogenital HR-HPV acquisition and persistence. Primary and secondary prevention programs for HPV infection and HPV-related diseases should be prioritized for PHIV children and youth. 2020-11-18T09:54:52Z 2020-11-18T09:54:52Z 2020-11-05 Article Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Vol.71, No.8 (2020), e270-e280 10.1093/cid/ciz1143 15376591 2-s2.0-85095861725 https://repository.li.mahidol.ac.th/handle/123456789/60030 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85095861725&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Nittaya Phanuphak
Sirinya Teeraananchai
Rawiwan Hansudewechakul
Sivaporn Gatechompol
Kulkanya Chokephaibulkit
Hanh Le Dung Dang
Dan Ngoc Hanh Tran
Jullapong Achalapong
Nipat Teeratakulpisarn
Amphan Chalermchockcharoenkit
Manopchai Thamkhantho
Tippawan Pankam
Thida Singtoroj
Wichai Termrungruanglert
Surasith Chaithongwongwatthana
Stephen J. Kerr
Annette H. Sohn
Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study
description © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: Female youth with perinatally acquired human immunodeficiency virus (PHIV) may be at higher risk than uninfected youth for persistent anogenital human papillomavirus (HPV) infection, due to prolonged immunodeficiency. METHODS: A 3-year cohort study was conducted between 2013 and 2017 among Thai and Vietnamese PHIV and HIV-uninfected females 12-24 years, matched by age group and number of lifetime sexual partners. For HPV genotyping, cervical and anal samples were obtained at baseline and annually. Vaginal samples were collected at baseline and every 6 months. Factors associated with high-risk HPV (HR-HPV) persistence and incidence were assessed. RESULTS: We enrolled 93 PHIV and 99 HIV-uninfected females. Median age was 19 (interquartile range [IQR] 18-20) years. For the 7 HR-HPV types (16, 18, 31, 33, 45, 52, 58) in the nonavalent HPV vaccine, PHIV had significantly higher incidence (P = .03) and persistence (P = .01) than HIV-uninfected youth over a 3-year period. Having HIV (adjusted hazard ratio [aHR] 2.1, 95% confidence interval [CI] 1.1-3.9) and ever using illegal substances (aHR 4.8, 95% CI 1.8-13.0) were associated with incident 7 HR-HPV infections. HIV-positive status (adjusted prevalence ratio [aPR] 2.2, 95% CI 1.5-3.2), recent alcohol use (aPR 1.75, 95% CI 1.2-2.5), and higher number of lifetime partners (aPR 2.0, 95% CI 1.4-3.1, for 3-5 partners; aPR 1.93, 95% CI 1.2-3.2, for ≥6 partners) were significantly associated with persistent 7 HR-HPV infections. CONCLUSIONS: Female PHIV were at higher risk of having anogenital HR-HPV acquisition and persistence. Primary and secondary prevention programs for HPV infection and HPV-related diseases should be prioritized for PHIV children and youth.
author2 Thai Red Cross Agency
author_facet Thai Red Cross Agency
Nittaya Phanuphak
Sirinya Teeraananchai
Rawiwan Hansudewechakul
Sivaporn Gatechompol
Kulkanya Chokephaibulkit
Hanh Le Dung Dang
Dan Ngoc Hanh Tran
Jullapong Achalapong
Nipat Teeratakulpisarn
Amphan Chalermchockcharoenkit
Manopchai Thamkhantho
Tippawan Pankam
Thida Singtoroj
Wichai Termrungruanglert
Surasith Chaithongwongwatthana
Stephen J. Kerr
Annette H. Sohn
format Article
author Nittaya Phanuphak
Sirinya Teeraananchai
Rawiwan Hansudewechakul
Sivaporn Gatechompol
Kulkanya Chokephaibulkit
Hanh Le Dung Dang
Dan Ngoc Hanh Tran
Jullapong Achalapong
Nipat Teeratakulpisarn
Amphan Chalermchockcharoenkit
Manopchai Thamkhantho
Tippawan Pankam
Thida Singtoroj
Wichai Termrungruanglert
Surasith Chaithongwongwatthana
Stephen J. Kerr
Annette H. Sohn
author_sort Nittaya Phanuphak
title Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study
title_short Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study
title_full Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study
title_fullStr Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study
title_full_unstemmed Incidence and Persistence of High-risk Anogenital Human Papillomavirus Infection Among Female Youth With and Without Perinatally Acquired Human Immunodefiency Virus Infection: A 3-year Observational Cohort Study
title_sort incidence and persistence of high-risk anogenital human papillomavirus infection among female youth with and without perinatally acquired human immunodefiency virus infection: a 3-year observational cohort study
publishDate 2020
url https://repository.li.mahidol.ac.th/handle/123456789/60030
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