The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach

The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach

The capacity of α-mangostin (α-MG) and β-mangostin (β-MG) from mangosteen pericarp on P-glycoprotein (Pgp) in silico, in vitro, and ex vivo was investigated in this study. Screening with the ADMET Predictor™ program predicted the two compounds to be both a Pgp inhibitor and Pgp substrate. The compou...

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Main Authors: Panudda Dechwongya, Songpol Limpisood, Nawong Boonnak, Supachoke Mangmool, Mariko Takeda-Morishita, Thitianan Kulsirirat, Pattarawit Rukthong, Korbtham Sathirakul
Other Authors: Mahidol University
Format: Article
Published: 2021
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/60870
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/60870

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