Neuroprotection of HydroxynicotinylAmide 18 against Lipid Peroxidationand,Memory Impairment

• Main Authors: Opa Vajragupta, Orawan Monthakantirat, Preecha Boonchoong, Hiroshi Watanabe, Penchom Peungvicha
• Other Authors: Mahidol Univesity. Faculty of Pharmacy. Department of Pharmaceutical Chemistry
• Format: Article
• Language: English
• Published: 2010
• Subjects: Hydroxylnicotinyl amide; Lipid peroxidation; Radical scavenger; Locomotor; Memory; Water maze
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/62112
• Institution: Mahidol University

Hydroxynicotinyl amide 18, a novel radical-scavenging agent, was developed for neuroprotection. 18 showed substantial ex vivo inhibitory action against lipid peroxidation in mice brain regardless of low in vitro inhibition. These indicated that 18 effectively reached the brain, the target site. Elec...