Association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection
Joint International Tropical Medicine Meeting 2013: Towards global health: an Asian paradigm of Tropical Medicine 11-13 December 2013 Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2013. p.162.
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2015
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th-mahidol.633582021-08-30T22:41:06Z Association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection Nada Pitabut นฎา ปิตะบุตร Shinsaku Sakurada Takahiro Tanaka Panadda Dhepakson Hideki Yanai Norio Yamada Masaji Okada Naoto Keicho Srisin Khusmith ศรีสิน คูสมิทธิ์ Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology Granulysin HIV Lymphocytes Subsets Joint International Tropical Medicine Meeting 2013: Towards global health: an Asian paradigm of Tropical Medicine 11-13 December 2013 Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2013. p.162. Host effector mechanism against Mycobacterium tuberculosis infection is dependent on innate immune response by macrophages and neutrophils and alterations in balanced adaptive immunity. Coordinated release of cytolytic effector molecules from NK cells and effector T cells and the subsequent granule-associated killing of infected cells have been documented; however, their potential role in clinical tuberculosis is still controversy. This study aims to investigate whether circulating granulysin and other effector molecules are associated with the number of NK cells, iNKT cells, Vγ9+Vδ2+ T cells, CD4+ T cells and CD8+ T cells, and such association influences the clinical outcome of the disease in patients with pulmonary TB and HIV/TB coinfection who have been living in Chiang Rai, north of Thailand where TB is endemic. Granulysin and perforin levels in TB patients were lower than healthy controls, whereas much higher granulysin levels in HIV/TB coinfection than in any other groups, TB and HIV with or without receiving HAART were noted. Such higher levels corresponded to the number of CD8+ T cells which kept high, but not with NK cells and other possible cellular sources of granulysin. In addition, the 17kDa, 15kDa and 9kDa isoforms of granulysin were recognized in plasma of HIV/TB coinfection. Increased granulysin and decreased IFN-γ levels in HIV/TB coinfection and TB after completion of anti-TB therapy were observed. The results suggested that the alteration of circulating granulysin has potential function in host immune response against TB and HIV/TB coinfection. This is the first demonstration so far of granulysin in HIV/TB coinfection. 2015-10-26T05:58:06Z 2021-08-30T15:41:06Z 2015-10-26T05:58:06Z 2021-08-30T15:41:06Z 2015-10-26 2013 Proceeding Poster https://repository.li.mahidol.ac.th/handle/123456789/63358 eng Mahidol University |
| institution |
Mahidol University |
| building |
Mahidol University Library |
| continent |
Asia |
| country |
Thailand Thailand |
| content_provider |
Mahidol University Library |
| collection |
Mahidol University Institutional Repository |
| language |
English |
| topic |
Granulysin HIV Lymphocytes Subsets |
| spellingShingle |
Granulysin HIV Lymphocytes Subsets Nada Pitabut นฎา ปิตะบุตร Shinsaku Sakurada Takahiro Tanaka Panadda Dhepakson Hideki Yanai Norio Yamada Masaji Okada Naoto Keicho Srisin Khusmith ศรีสิน คูสมิทธิ์ Association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection |
| description |
Joint International Tropical Medicine Meeting 2013: Towards global health: an Asian paradigm of Tropical Medicine 11-13 December 2013 Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2013. p.162. |
| author2 |
Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology |
| author_facet |
Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology Nada Pitabut นฎา ปิตะบุตร Shinsaku Sakurada Takahiro Tanaka Panadda Dhepakson Hideki Yanai Norio Yamada Masaji Okada Naoto Keicho Srisin Khusmith ศรีสิน คูสมิทธิ์ |
| format |
Proceeding Poster |
| author |
Nada Pitabut นฎา ปิตะบุตร Shinsaku Sakurada Takahiro Tanaka Panadda Dhepakson Hideki Yanai Norio Yamada Masaji Okada Naoto Keicho Srisin Khusmith ศรีสิน คูสมิทธิ์ |
| author_sort |
Nada Pitabut |
| title |
Association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection |
| title_short |
Association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection |
| title_full |
Association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection |
| title_fullStr |
Association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection |
| title_full_unstemmed |
Association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection |
| title_sort |
association of granulysin, perforin, ifn-γ and lymphocyte subsets influences the clinical outcome in thai patients with tb and hiv/tb coinfection |
| publishDate |
2015 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/63358 |
| _version_ |
1763490486453010432 |