Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria

• Main Authors: Ronnatrai Ruangweerayut, รณไตร เรืองวีรยุทธ, Sornchai Looareesuwan, ศรชัย หลูอารีย์สุวรรณ, Hutchinson, David, Anurak Chauemung, Vick Banmairuroi, Kesara Na-Bangchang
• Format: Article
• Language: English
• Published: 2013
• Subjects: Antimalarials; Area under curve; Clindamycin; Drug therapy, combination; Fosfomycin; Malaria, Falciparum; Metabolic clearance rate; Plasma; Plasmodium falciparum; Treatment outcome; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/710
• Institution: Mahidol University

BACKGROUND: This study investigated the pharmacokinetics of fosmidomycin when given in combination with clindamycin at two dosage regimens in patients with acute uncomplicated falciparum malaria. METHODS: A total of 70 patients with acute uncomplicated Plasmodium falciparum malaria who fulfilled...