Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection
BACKGROUND: It has frequently been reported that Plasmodium vivax suppressed Plasmodium falciparum and ameliorated disease severity in patients infected with these two species simultaneously. The authors investigate the hypothesis that immunological responses stimulated by P. vivax may play a ro...
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th-mahidol.7212023-03-31T00:36:42Z Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection Nagao, Yoshiro Kimura-Sato, Masako Porntip Chavalitshewinkoon-Petmitr พรทิพย์ เพ็ชรมิตร Supatra Thongrungkiat สุพัตรา ทองรุ่งเกียรติ Polrat Wilairatana พลรัตน์ วิไลรัตน์ Ishida, Takafumi Peerapan Tan-ariya Souza, J. Brian de Srivicha Krudsood ศรีวิชา ครุฑสูตร Sornchai Looareesuwan ศรชัย หลูอารีย์สุวรรณ Nagao, Yoshiro Mahidol University. Faculty of Tropical Medicine. Antibodies, Protozoan Antigens, Protozoan Cross Reactions Plasmodium falciparum Plasmodium vivax Open Access article BACKGROUND: It has frequently been reported that Plasmodium vivax suppressed Plasmodium falciparum and ameliorated disease severity in patients infected with these two species simultaneously. The authors investigate the hypothesis that immunological responses stimulated by P. vivax may play a role in suppressing co-infecting P. falciparum. METHODS: Sera, taken sequentially from one of the authors (YN) during experimental infection with P. vivax, were added to in vitro cultures of P. falciparum. Cross-reactive antibodies against P. falciparum antigens, and cytokines were measured in the sera. RESULTS: Significant growth inhibitory effects upon P. falciparum cultures (maximally 68% inhibition as compared to pre-illness average) were observed in the sera collected during an acute episode. Such inhibitory effects showed a strong positive temporal correlation with cross-reactive antibodies, especially IgM against P. falciparum schizont extract and, to a lesser degree, IgM against Merozoite Surface Protein (MSP)-119. Interleukin (IL)-12 showed the highest temporal correlation with P. vivax parasitaemia and with body temperatures in the volunteer. CONCLUSION: These results suggest the involvement by cross-reactive antibodies, especially IgM, in the interplay between plasmodial species. IL-12 may be one of direct mediators of fever induction by rupturing P. vivax schizonts, at least in some subjects. Future studies, preferably of epidemiological design, to reveal the association between cross-reactive IgM and cross-plasmodial interaction, are warranted. 2012-12-18T03:48:43Z 2016-09-26T01:51:50Z 2012-12-18T03:48:43Z 2016-09-26T01:51:50Z 2008 2012-12-18 2008-06-26 Article Nagao Y, Kimura-Sato M, Chavalitshewinkoon-Petmitr P, Thongrungkiat S, Wilairatana P, Ishida T, et al. Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection. Malar J. 2008 Jun 26;7:113. 10.1186/1475-2875-7-113 1475-2875 (electronic) https://repository.li.mahidol.ac.th/handle/123456789/721 eng Mahidol University BioMed Central application/pdf |
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Antibodies, Protozoan Antigens, Protozoan Cross Reactions Plasmodium falciparum Plasmodium vivax Open Access article |
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Antibodies, Protozoan Antigens, Protozoan Cross Reactions Plasmodium falciparum Plasmodium vivax Open Access article Nagao, Yoshiro Kimura-Sato, Masako Porntip Chavalitshewinkoon-Petmitr พรทิพย์ เพ็ชรมิตร Supatra Thongrungkiat สุพัตรา ทองรุ่งเกียรติ Polrat Wilairatana พลรัตน์ วิไลรัตน์ Ishida, Takafumi Peerapan Tan-ariya Souza, J. Brian de Srivicha Krudsood ศรีวิชา ครุฑสูตร Sornchai Looareesuwan ศรชัย หลูอารีย์สุวรรณ Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection |
description |
BACKGROUND: It has frequently been reported that Plasmodium vivax suppressed
Plasmodium falciparum and ameliorated disease severity in patients infected with
these two species simultaneously. The authors investigate the hypothesis that
immunological responses stimulated by P. vivax may play a role in suppressing
co-infecting P. falciparum.
METHODS: Sera, taken sequentially from one of the authors (YN) during
experimental infection with P. vivax, were added to in vitro cultures of P.
falciparum. Cross-reactive antibodies against P. falciparum antigens, and
cytokines were measured in the sera.
RESULTS: Significant growth inhibitory effects upon P. falciparum cultures
(maximally 68% inhibition as compared to pre-illness average) were observed in
the sera collected during an acute episode. Such inhibitory effects showed a
strong positive temporal correlation with cross-reactive antibodies, especially
IgM against P. falciparum schizont extract and, to a lesser degree, IgM against
Merozoite Surface Protein (MSP)-119. Interleukin (IL)-12 showed the highest
temporal correlation with P. vivax parasitaemia and with body temperatures in the
volunteer.
CONCLUSION: These results suggest the involvement by cross-reactive antibodies,
especially IgM, in the interplay between plasmodial species. IL-12 may be one of
direct mediators of fever induction by rupturing P. vivax schizonts, at least in
some subjects. Future studies, preferably of epidemiological design, to reveal
the association between cross-reactive IgM and cross-plasmodial interaction, are
warranted. |
author2 |
Nagao, Yoshiro |
author_facet |
Nagao, Yoshiro Nagao, Yoshiro Kimura-Sato, Masako Porntip Chavalitshewinkoon-Petmitr พรทิพย์ เพ็ชรมิตร Supatra Thongrungkiat สุพัตรา ทองรุ่งเกียรติ Polrat Wilairatana พลรัตน์ วิไลรัตน์ Ishida, Takafumi Peerapan Tan-ariya Souza, J. Brian de Srivicha Krudsood ศรีวิชา ครุฑสูตร Sornchai Looareesuwan ศรชัย หลูอารีย์สุวรรณ |
format |
Article |
author |
Nagao, Yoshiro Kimura-Sato, Masako Porntip Chavalitshewinkoon-Petmitr พรทิพย์ เพ็ชรมิตร Supatra Thongrungkiat สุพัตรา ทองรุ่งเกียรติ Polrat Wilairatana พลรัตน์ วิไลรัตน์ Ishida, Takafumi Peerapan Tan-ariya Souza, J. Brian de Srivicha Krudsood ศรีวิชา ครุฑสูตร Sornchai Looareesuwan ศรชัย หลูอารีย์สุวรรณ |
author_sort |
Nagao, Yoshiro |
title |
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection |
title_short |
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection |
title_full |
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection |
title_fullStr |
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection |
title_full_unstemmed |
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection |
title_sort |
suppression of plasmodium falciparum by serum collected from a case of plasmodium vivax infection |
publishDate |
2012 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/721 |
_version_ |
1763495078018416640 |