Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria

• Main Authors: Stephanie I. Studniberg, Lisa J. Ioannidis, Retno A.S. Utami, Leily Trianty, Yang Liao, Waruni Abeysekera, Connie S.N. Li-Wai-Suen, Halina M. Pietrzak, Julie Healer, Agatha M. Puspitasari, Dwi Apriyanti, Farah Coutrier, Jeanne R. Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K. Smyth, Alan F. Cowman, Ric N. Price, Rintis Noviyanti, Wei Shi, Alexandra L. Garnham, Diana S. Hansen
• Other Authors: School of Mathematics and Statistics
• Format: Article
• Published: 2022
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Mathematics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73035
• Institution: Mahidol University

Clinical immunity to P. falciparum malaria is non-sterilizing, with adults often experiencing asymptomatic infection. Historically, asymptomatic malaria has been viewed as beneficial and required to help maintain clinical immunity. Emerging views suggest that these infections are detrimental and con...