The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state

• Main Authors: Sharanjeet Atwal, Jantana Wongsantichon, Suparat Giengkam, Kittirat Saharat, Yanin Jaiyen Pittayasathornthun, Suthida Chuenklin, Loo Chien Wang, Taerin Chung, Hyun Huh, Sang Hyuk Lee, Radoslaw M. Sobota, Jeanne Salje
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Physics and Astronomy; Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73209
• Institution: Mahidol University

Orientia tsutsugamushi (Ot) is an obligate intracellular bacterium in the family Rickettsiaceae that causes scrub typhus, a severe mite-borne human disease. Its mechanism of cell exit is unusual amongst Rickettsiaceae, as Ot buds off the surface of infected cells enveloped in plasma membrane. Here,...