Distinct responses between healthy and cirrhotic human livers upon lipopolysaccharide challenge: possible implications for acute-on-chronic liver failure

• Main Authors: Su Suriguga, Mei Li, Theerut Luangmonkong, Miriam Boersema, Koert P. de Jong, Dorenda Oosterhuis, A. R. Gorter, Leonie Beljaars, Peter Olinga
• Other Authors: Neimenggu Agricultural University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73233
• Institution: Mahidol University

Patients with acute-on-chronic liver failure (ACLF) are at risk of developing acute hepatic decompensation and organ failures with an unraveled complex mechanism. An altered immune response toward insults in cirrhotic compared with healthy livers may contribute to the ACLF development. Therefore, we...