The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics

Exosomes are the self-packed nanoscale vesicles (nanovesicles) derived from late endosomes and released from the cells to the extracellular milieu. Exosomal biogenesis is based on endosomal pathway to form the nanovesicles surrounded by membrane originated from plasma membranes of the parental cells...

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Main Authors: Visith Thongboonkerd, Rattiyaporn Kanlaya
Other Authors: Siriraj Hospital
Format: Article
Published: 2022
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/73236
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spelling th-mahidol.732362022-08-04T10:39:01Z The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics Visith Thongboonkerd Rattiyaporn Kanlaya Siriraj Hospital Biochemistry, Genetics and Molecular Biology Exosomes are the self-packed nanoscale vesicles (nanovesicles) derived from late endosomes and released from the cells to the extracellular milieu. Exosomal biogenesis is based on endosomal pathway to form the nanovesicles surrounded by membrane originated from plasma membranes of the parental cells. During biogenesis, exosomes selectively encapsulate an array of biomolecules (proteins, nucleic acids, lipids, metabolites, etc.), thereby conveying diverse messages for cell-cell communications. Once released, these exosomal contents trigger signaling and trafficking that play roles in cell growth, development, immune responses, homeostasis, remodeling, etc. Recent advances in exosomal research have provided a wealth of useful information that enhances our knowledge on the roles for exosomes in pathogenic mechanisms of human diseases involving a wide variety of organ systems. In the kidney, exosomes play divergent roles, ranging from pathogenesis to therapeutics, based on their original sources and type of interventions. Herein, we summarize and update the current knowledge on the divergent roles of exosomes involving the pathogenesis, diagnostics, prognostics, and therapeutics in various groups of kidney diseases, including acute kidney injury, immune-mediated kidney diseases (e.g., IgA nephropathy, lupus nephritis, membranous nephropathy, focal segmental glomerulosclerosis), chronic kidney disease (caused by diabetic nephropathy and others), renal cell carcinoma, nephrolithiasis, kidney transplantation and related complications, and polycystic kidney disease. Finally, the future perspectives on research in this area are discussed. 2022-08-04T03:39:01Z 2022-08-04T03:39:01Z 2022-08-01 Article International Journal of Biochemistry and Cell Biology. Vol.149, (2022) 10.1016/j.biocel.2022.106262 18785875 13572725 2-s2.0-85133897463 https://repository.li.mahidol.ac.th/handle/123456789/73236 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133897463&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Visith Thongboonkerd
Rattiyaporn Kanlaya
The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics
description Exosomes are the self-packed nanoscale vesicles (nanovesicles) derived from late endosomes and released from the cells to the extracellular milieu. Exosomal biogenesis is based on endosomal pathway to form the nanovesicles surrounded by membrane originated from plasma membranes of the parental cells. During biogenesis, exosomes selectively encapsulate an array of biomolecules (proteins, nucleic acids, lipids, metabolites, etc.), thereby conveying diverse messages for cell-cell communications. Once released, these exosomal contents trigger signaling and trafficking that play roles in cell growth, development, immune responses, homeostasis, remodeling, etc. Recent advances in exosomal research have provided a wealth of useful information that enhances our knowledge on the roles for exosomes in pathogenic mechanisms of human diseases involving a wide variety of organ systems. In the kidney, exosomes play divergent roles, ranging from pathogenesis to therapeutics, based on their original sources and type of interventions. Herein, we summarize and update the current knowledge on the divergent roles of exosomes involving the pathogenesis, diagnostics, prognostics, and therapeutics in various groups of kidney diseases, including acute kidney injury, immune-mediated kidney diseases (e.g., IgA nephropathy, lupus nephritis, membranous nephropathy, focal segmental glomerulosclerosis), chronic kidney disease (caused by diabetic nephropathy and others), renal cell carcinoma, nephrolithiasis, kidney transplantation and related complications, and polycystic kidney disease. Finally, the future perspectives on research in this area are discussed.
author2 Siriraj Hospital
author_facet Siriraj Hospital
Visith Thongboonkerd
Rattiyaporn Kanlaya
format Article
author Visith Thongboonkerd
Rattiyaporn Kanlaya
author_sort Visith Thongboonkerd
title The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics
title_short The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics
title_full The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics
title_fullStr The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics
title_full_unstemmed The divergent roles of exosomes in kidney diseases: Pathogenesis, diagnostics, prognostics and therapeutics
title_sort divergent roles of exosomes in kidney diseases: pathogenesis, diagnostics, prognostics and therapeutics
publishDate 2022
url https://repository.li.mahidol.ac.th/handle/123456789/73236
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