Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause

Objective: To compare the effects of 6% Pueraria mirifica vaginal gel with those of placebo gel on vaginal blood flow, vaginal maturation index (VMI), vaginal health index (VHI), endometrial thickness and genitourinary symptoms in postmenopausal women. Study design: In a randomized, double-blinded,...

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Main Authors: Patsira Warinsiriruk, Chananya Tantitham, Wichai Cherdshewasart, S. Abbas Shobeiri, Jittima Manonai
Other Authors: Chulalongkorn University
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Published: 2022
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/73312
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spelling th-mahidol.733122022-08-04T11:21:12Z Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause Patsira Warinsiriruk Chananya Tantitham Wichai Cherdshewasart S. Abbas Shobeiri Jittima Manonai Chulalongkorn University Faculty of Medicine Ramathibodi Hospital, Mahidol University Inova Women's Hospital Biochemistry, Genetics and Molecular Biology Medicine Objective: To compare the effects of 6% Pueraria mirifica vaginal gel with those of placebo gel on vaginal blood flow, vaginal maturation index (VMI), vaginal health index (VHI), endometrial thickness and genitourinary symptoms in postmenopausal women. Study design: In a randomized, double-blinded, placebo-controlled study (TCTR20200624007), 72 postmenopausal women were randomized into the P. mirifica or the placebo gel group. Both groups were followed up at week 4 and week 12. Main outcome measure: Doppler ultrasonography pulsatility index (PI) and resistance index (RI), VMI, VHI, endometrial thickness and genitourinary symptoms were evaluated at baseline, at week 4 and week 12 of treatment. Results: Sixty-three participants completed the study. After 4 and 12 weeks of treatment, PI and RI had significantly decreased in the P. mirifica group compared with the placebo group. At week 12, PI in the P. mirifica group and in the placebo group were 3.03 + 1.09 and 6.88 + 2.16, respectively (p = 0.002). Similar changes were also demonstrated in the resistance indices. The P. mirifica group demonstrated a markedly higher mean VMI at week 12 compared with the placebo group, 55.19 ± 18.53 and 20.29 ± 28.46 (p = 0.012). In addition, all parameters of VHI based on the vaginal physical findings at week 12 in the P. mirifica group were significantly higher than in the placebo group (p < 0.001). Conclusion: In this study, 6% P. mirifica vaginal gel for 12 weeks in postmenopausal women with GSM appeared to increase vaginal artery circulation and restore atrophic vaginal tissue. Clinical Trial Registration Number: TCTR20200624007. 2022-08-04T03:40:47Z 2022-08-04T03:40:47Z 2022-06-01 Article Maturitas. Vol.160, (2022), 4-10 10.1016/j.maturitas.2022.01.005 18734111 03785122 2-s2.0-85123852827 https://repository.li.mahidol.ac.th/handle/123456789/73312 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123852827&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Patsira Warinsiriruk
Chananya Tantitham
Wichai Cherdshewasart
S. Abbas Shobeiri
Jittima Manonai
Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause
description Objective: To compare the effects of 6% Pueraria mirifica vaginal gel with those of placebo gel on vaginal blood flow, vaginal maturation index (VMI), vaginal health index (VHI), endometrial thickness and genitourinary symptoms in postmenopausal women. Study design: In a randomized, double-blinded, placebo-controlled study (TCTR20200624007), 72 postmenopausal women were randomized into the P. mirifica or the placebo gel group. Both groups were followed up at week 4 and week 12. Main outcome measure: Doppler ultrasonography pulsatility index (PI) and resistance index (RI), VMI, VHI, endometrial thickness and genitourinary symptoms were evaluated at baseline, at week 4 and week 12 of treatment. Results: Sixty-three participants completed the study. After 4 and 12 weeks of treatment, PI and RI had significantly decreased in the P. mirifica group compared with the placebo group. At week 12, PI in the P. mirifica group and in the placebo group were 3.03 + 1.09 and 6.88 + 2.16, respectively (p = 0.002). Similar changes were also demonstrated in the resistance indices. The P. mirifica group demonstrated a markedly higher mean VMI at week 12 compared with the placebo group, 55.19 ± 18.53 and 20.29 ± 28.46 (p = 0.012). In addition, all parameters of VHI based on the vaginal physical findings at week 12 in the P. mirifica group were significantly higher than in the placebo group (p < 0.001). Conclusion: In this study, 6% P. mirifica vaginal gel for 12 weeks in postmenopausal women with GSM appeared to increase vaginal artery circulation and restore atrophic vaginal tissue. Clinical Trial Registration Number: TCTR20200624007.
author2 Chulalongkorn University
author_facet Chulalongkorn University
Patsira Warinsiriruk
Chananya Tantitham
Wichai Cherdshewasart
S. Abbas Shobeiri
Jittima Manonai
format Article
author Patsira Warinsiriruk
Chananya Tantitham
Wichai Cherdshewasart
S. Abbas Shobeiri
Jittima Manonai
author_sort Patsira Warinsiriruk
title Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause
title_short Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause
title_full Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause
title_fullStr Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause
title_full_unstemmed Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause
title_sort effects of pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause
publishDate 2022
url https://repository.li.mahidol.ac.th/handle/123456789/73312
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