Pinostrobin inhibits renal CFTR-mediated Cl⁻ secretion and retards cyst growth in cell-derived cyst and polycystic kidney disease rats

• Main Authors: Kanlayanee Tonum, Napason Chabang, Somsak Fongsupa, Suphat Chantawarin, Chutima Jiarpinitnun, Patoomrattana Tuchinda, Sunhapas Soodvilai
• Other Authors: Mahidol University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73377

Cystic fibrosis transmembrane conductance regulator (CFTR) plays crucial role in renal cyst expansion via increase in fluid accumulation. Inhibition of CFTR has been proposed to retard cyst development and enlargement in polycystic kidney disease (PKD). Pinostrobin, a bioactive natural flavonoid, po...