Generation of an induced pluripotent stem cell line (MUSIi014-A) from an affected member of a family with autosomal dominant diabetes carrying p.L475P mutation in ZYG11A gene associated with a cell cycle arrest in beta-cell

• Main Authors: Chutima Chanprasert, Nutchanawan Promnakhon, Nontaphat Thongsin, Siriwal Suwanpitak, Nattachet Plengvidhya, Pa thai Yenchitsommanus, Prapaporn Jungtrakoon Thamtarana, Methichit Wattanapanitch
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73379
• Institution: Mahidol University

A heterozygous mutation (c.T1424C: p.L475P) in ZYG11A completely segregating with hyperglycemia in a Thai family with familial diabetes of the adulthood has been reported as a cause of cell cycle arrest in 1.1B4 cell line. This mutation is a suggestive cause of failure in adaptive beta-cell expansio...