Identification of tripeptides against tyrosine kinase domain of EGFR for lung cancer cell inhibition by in silico and in vitro studies

• Main Authors: Duangnapa Kiriwan, Supaphorn Seetaha, Nattanan Jiwacharoenchai, Lueacha Tabtimmai, Sérgio F. Sousa, Napat Songtawee, Kiattawee Choowongkomon
• Other Authors: King Mongkut's University of Technology North Bangkok
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73411
• Institution: Mahidol University

Epidermal growth factor receptor tyrosine kinase domain (EGFR-TK) has been one of the prominent targets for therapeutics of several human cancers, in particular non-small cell lung cancer. Although several small chemical compounds targeting EGFR-TK have been approved by FDA for treatment of such a c...