B1 siRNA Increases de novo DNA Methylation of B1 Elements and Promotes Wound Healing in Diabetic Rats

• Main Authors: Sakawdaurn Yasom, Wilunplus Khumsri, Papatson Boonsongserm, Nakarin Kitkumthorn, Preecha Ruangvejvorachai, Apasee Sooksamran, Rujira Wanotayan, Apiwat Mutirangura
• Other Authors: Mahidol University, Faculty of Dentistry
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73464
• Institution: Mahidol University

Alu (B1 in rodents) hypomethylation, commonly found in diabetes mellitus patients, increases DNA damage and, consequently, delays the healing process. Alu siRNA increases Alu methylation, reduces DNA damage, and promotes cell proliferation. Aim: To explore whether B1 siRNA treatment restores B1 hypo...