Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children

• Main Authors: Damian A. Oyong, Jessica R. Loughland, Megan S.F. Soon, Jo Anne Chan, Dean Andrew, Bruce D. Wines, P. Mark Hogarth, Stuart D. Olver, Alika D. Collinge, Antiopi Varelias, James G. Beeson, Enny Kenangalem, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Michelle J. Boyle
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/73536
• Institution: Mahidol University

Background: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure, however the cellular responses mediating these differences are unknown. CD4 T-follicular helper (Tfh) cells have key roles in inducing antibodies, with Th2-Tfh cell act...