Molecularly Imprinted Polymer Functionalized on Reduced Graphene Oxide Electrochemical Sensor for Detection of Ciprofloxacin
Ciprofloxacin (CIP) is widely utilised to treat bacterial infections. Currently, CIP is present in water sources at higher concentrations, thus necessitating close monitoring. This study developed electrochemical nano-sensors based on molecularly imprinted polymer (MIP) and reduced graphene oxide (r...
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th-mahidol.738612022-08-04T11:03:50Z Molecularly Imprinted Polymer Functionalized on Reduced Graphene Oxide Electrochemical Sensor for Detection of Ciprofloxacin Jedsada Chuiprasert Suwanna Kitpati Boontanon Sira Srinives Narin Boontanon Chongrak Polprasert Nudjarin Ramungul Graduate School of Global Environmental Studies Faculty of Environment and Resource Studies, Mahidol University Thailand National Metal and Materials Technology Center Mahidol University Thammasat University Earth and Planetary Sciences Environmental Science Ciprofloxacin (CIP) is widely utilised to treat bacterial infections. Currently, CIP is present in water sources at higher concentrations, thus necessitating close monitoring. This study developed electrochemical nano-sensors based on molecularly imprinted polymer (MIP) and reduced graphene oxide (rGO) composites to detect CIP. rGO served as the loading platform for MIP immobilisation on a glassy carbon electrode (GCE). A copolymer thin film, comprised of polyaniline copolymerized with o-phenylenediamine (PAni-co-PDA) was obtained by electro-polymerisation utilizing cyclic voltammetry (CV) under suitable conditions. The performance of the modified GCE was examined utilizing CV mode in a hexacyanoferrate electrolyte as an electrochemical probe. The PAni-co-PDA/rGO-modified GCE exhibited enhanced improvement and efficient electrocatalytic behaviour in the oxidation of CIP with relatively high sensitivity and stability. The sensor was operated in differential pulse voltammetry (DPV) mode. Our best results revealed good linearity response to CIP in the range of 0.001-10.0 μM with an R-squared of 0.949, a detection limit of 0.09 μM (3.3 SD/S), and the calibration plot of "I minus the logarithm of the CIP concentration exhibited a sensitivity of -1.521. The sensor demonstrated a conductive polymer-based device that can be utilised for rapid CIP determination in pharmaceutical samples and biological fluids. 2022-08-04T03:56:42Z 2022-08-04T03:56:42Z 2022-02-02 Conference Paper IOP Conference Series: Earth and Environmental Science. Vol.973, No.1 (2022) 10.1088/1755-1315/973/1/012003 17551315 17551307 2-s2.0-85124977652 https://repository.li.mahidol.ac.th/handle/123456789/73861 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85124977652&origin=inward |
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Earth and Planetary Sciences Environmental Science Jedsada Chuiprasert Suwanna Kitpati Boontanon Sira Srinives Narin Boontanon Chongrak Polprasert Nudjarin Ramungul Molecularly Imprinted Polymer Functionalized on Reduced Graphene Oxide Electrochemical Sensor for Detection of Ciprofloxacin |
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Ciprofloxacin (CIP) is widely utilised to treat bacterial infections. Currently, CIP is present in water sources at higher concentrations, thus necessitating close monitoring. This study developed electrochemical nano-sensors based on molecularly imprinted polymer (MIP) and reduced graphene oxide (rGO) composites to detect CIP. rGO served as the loading platform for MIP immobilisation on a glassy carbon electrode (GCE). A copolymer thin film, comprised of polyaniline copolymerized with o-phenylenediamine (PAni-co-PDA) was obtained by electro-polymerisation utilizing cyclic voltammetry (CV) under suitable conditions. The performance of the modified GCE was examined utilizing CV mode in a hexacyanoferrate electrolyte as an electrochemical probe. The PAni-co-PDA/rGO-modified GCE exhibited enhanced improvement and efficient electrocatalytic behaviour in the oxidation of CIP with relatively high sensitivity and stability. The sensor was operated in differential pulse voltammetry (DPV) mode. Our best results revealed good linearity response to CIP in the range of 0.001-10.0 μM with an R-squared of 0.949, a detection limit of 0.09 μM (3.3 SD/S), and the calibration plot of "I minus the logarithm of the CIP concentration exhibited a sensitivity of -1.521. The sensor demonstrated a conductive polymer-based device that can be utilised for rapid CIP determination in pharmaceutical samples and biological fluids. |
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Graduate School of Global Environmental Studies |
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Graduate School of Global Environmental Studies Jedsada Chuiprasert Suwanna Kitpati Boontanon Sira Srinives Narin Boontanon Chongrak Polprasert Nudjarin Ramungul |
format |
Conference or Workshop Item |
author |
Jedsada Chuiprasert Suwanna Kitpati Boontanon Sira Srinives Narin Boontanon Chongrak Polprasert Nudjarin Ramungul |
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Jedsada Chuiprasert |
title |
Molecularly Imprinted Polymer Functionalized on Reduced Graphene Oxide Electrochemical Sensor for Detection of Ciprofloxacin |
title_short |
Molecularly Imprinted Polymer Functionalized on Reduced Graphene Oxide Electrochemical Sensor for Detection of Ciprofloxacin |
title_full |
Molecularly Imprinted Polymer Functionalized on Reduced Graphene Oxide Electrochemical Sensor for Detection of Ciprofloxacin |
title_fullStr |
Molecularly Imprinted Polymer Functionalized on Reduced Graphene Oxide Electrochemical Sensor for Detection of Ciprofloxacin |
title_full_unstemmed |
Molecularly Imprinted Polymer Functionalized on Reduced Graphene Oxide Electrochemical Sensor for Detection of Ciprofloxacin |
title_sort |
molecularly imprinted polymer functionalized on reduced graphene oxide electrochemical sensor for detection of ciprofloxacin |
publishDate |
2022 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/73861 |
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1763490582629449728 |