Pharmacokinetic considerations in seasonal malaria chemoprevention
African children under 5 years of age bear the main burden of global malaria mortality. Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) given monthly during the rainy season is a highly effective malaria intervention for children aged between 3 months...
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th-mahidol.740902022-08-04T11:16:20Z Pharmacokinetic considerations in seasonal malaria chemoprevention Palang Chotsiri Nicholas J. White Joel Tarning Faculty of Tropical Medicine, Mahidol University Nuffield Department of Medicine Immunology and Microbiology Medicine African children under 5 years of age bear the main burden of global malaria mortality. Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) given monthly during the rainy season is a highly effective malaria intervention for children aged between 3 months and 5 years living in the Sahel region, a region of intense but seasonal malaria transmission. This intervention is now being considered for other regions of Africa where malaria parasites are more drug resistant. Dihydroartemisinin-piperaquine (DP), an artemisinin-based combination therapy (ACT), has proved to be highly effective and well tolerated in intermittent preventive treatment in pregnant women and children. This combination may be a suitable alternative for SMC. Understanding the safety, pharmacokinetic and pharmacodynamic properties of antimalarial combination therapies is crucial in optimising dosing. 2022-08-04T04:06:45Z 2022-08-04T04:06:45Z 2022-08-01 Review Trends in Parasitology. Vol.38, No.8 (2022), 673-682 10.1016/j.pt.2022.05.003 14715007 14714922 2-s2.0-85131809192 https://repository.li.mahidol.ac.th/handle/123456789/74090 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131809192&origin=inward |
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Immunology and Microbiology Medicine Palang Chotsiri Nicholas J. White Joel Tarning Pharmacokinetic considerations in seasonal malaria chemoprevention |
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African children under 5 years of age bear the main burden of global malaria mortality. Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) given monthly during the rainy season is a highly effective malaria intervention for children aged between 3 months and 5 years living in the Sahel region, a region of intense but seasonal malaria transmission. This intervention is now being considered for other regions of Africa where malaria parasites are more drug resistant. Dihydroartemisinin-piperaquine (DP), an artemisinin-based combination therapy (ACT), has proved to be highly effective and well tolerated in intermittent preventive treatment in pregnant women and children. This combination may be a suitable alternative for SMC. Understanding the safety, pharmacokinetic and pharmacodynamic properties of antimalarial combination therapies is crucial in optimising dosing. |
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Faculty of Tropical Medicine, Mahidol University |
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Faculty of Tropical Medicine, Mahidol University Palang Chotsiri Nicholas J. White Joel Tarning |
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Review |
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Palang Chotsiri Nicholas J. White Joel Tarning |
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Palang Chotsiri |
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Pharmacokinetic considerations in seasonal malaria chemoprevention |
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Pharmacokinetic considerations in seasonal malaria chemoprevention |
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Pharmacokinetic considerations in seasonal malaria chemoprevention |
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Pharmacokinetic considerations in seasonal malaria chemoprevention |
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Pharmacokinetic considerations in seasonal malaria chemoprevention |
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pharmacokinetic considerations in seasonal malaria chemoprevention |
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2022 |
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https://repository.li.mahidol.ac.th/handle/123456789/74090 |
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