Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium
Background and Aim: Inflammatory bowel disease (IBD) is emerging in the newly industrialized countries of South Asia, South-East Asia, and the Middle East, yet epidemiological data are scarce. Methods: We performed a cross-sectional study of IBD demographics, disease phenotype, and treatment across...
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th-mahidol.744572022-08-04T11:19:50Z Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium Rupa Banerjee Partha Pal Ida Hilmi Uday C. Ghoshal Devendra C. Desai Mohammed Masudur Rahman Usha Dutta Syed A. Mohiuddin Munnera Al Mohannadi Mathew Philip Ganesh N. Ramesh Madunil A. Niriella Arjuna P. De Silva Hithanadura Janaka de Silva Pises Pisespongsa Julajak Limsrivilai Satimai Aniwan Metthananda Nawarathne Nilesh Fernandopulle Than Than Aye Nwe Ni Sameer Al Awadhi Neeraj Joshi Pham Thi V. Ngoc Tuan V. Kieu Anh Duong Nguyen Murdani Abdullah Ezzat Ali Ahmed Zeid Jose D. Sollano Bismillah Saberi Mahmoud Omar Mostafa Noor Mohsin Hafeza Aftab Tin Moe Wai Yogesh M. Shastri Sujit Chaudhuri Faruque Ahmed Shobna J. Bhatia Simon P.L. Travis Siriraj Hospital AMRI Hospitals Yangon General Hospital Hamad General Hospital University of Santo Tomas, Manila University of Kelaniya National Hospital of Sri Lanka Rashid Hospital NMC Specialty Hospital Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow P.D. Hinduja National Hospital and Medical Research Centre Dhaka Medical College and Hospital King Chulalongkorn Memorial Hospital Alexandria Medical School Bumrungrad International Hospital Asian Institute of Gastroenterology India University of Malaya Medical Centre Chittagong Medical College John Radcliffe Hospital Postgraduate Institute of Medical Education & Research, Chandigarh Aster Hospital New Mowasat Hospital Amiri Medical Complex Sir H.N. Reliance Foundation Hospital Nidan Hospital Bach Mai General Hospital Mandalay General Hospital University of Medicine 2 Lisie Hospital Medicine Background and Aim: Inflammatory bowel disease (IBD) is emerging in the newly industrialized countries of South Asia, South-East Asia, and the Middle East, yet epidemiological data are scarce. Methods: We performed a cross-sectional study of IBD demographics, disease phenotype, and treatment across 38 centers in 15 countries of South Asia, South-East Asia, and Middle East. Intergroup comparisons included gross national income (GNI) per capita. Results: Among 10 400 patients, ulcerative colitis (UC) was twice as common as Crohn's disease (CD), with a male predominance (UC 6678, CD 3495, IBD unclassified 227, and 58% male). Peak age of onset was in the third decade, with a low proportion of elderly-onset IBD (5% age > 60). Familial IBD was rare (5%). The extent of UC was predominantly distal (proctitis/left sided 67%), with most being treated with mesalamine (94%), steroids (54%), or immunomodulators (31%). Ileocolic CD (43%) was the commonest, with low rates of perianal disease (8%) and only 6% smokers. Diagnostic delay for CD was common (median 12 months; interquartile range 5–30). Treatment of CD included mesalamine, steroids, and immunomodulators (61%, 51%, and 56%, respectively), but a fifth received empirical antitubercular therapy. Treatment with biologics was uncommon (4% UC and 13% CD), which increased in countries with higher GNI per capita. Surgery rates were 0.1 (UC) and 2 (CD) per 100 patients per year. Conclusions: The IBD-ENC cohort provides insight into IBD in South-East Asia and the Middle East, but is not yet population based. UC is twice as common as CD, familial disease is uncommon, and rates of surgery are low. Biologic use correlates with per capita GNI. 2022-08-04T04:19:50Z 2022-08-04T04:19:50Z 2022-06-01 Article Journal of Gastroenterology and Hepatology (Australia). Vol.37, No.6 (2022), 1004-1015 10.1111/jgh.15801 14401746 08159319 2-s2.0-85132049824 https://repository.li.mahidol.ac.th/handle/123456789/74457 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85132049824&origin=inward |
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Medicine Rupa Banerjee Partha Pal Ida Hilmi Uday C. Ghoshal Devendra C. Desai Mohammed Masudur Rahman Usha Dutta Syed A. Mohiuddin Munnera Al Mohannadi Mathew Philip Ganesh N. Ramesh Madunil A. Niriella Arjuna P. De Silva Hithanadura Janaka de Silva Pises Pisespongsa Julajak Limsrivilai Satimai Aniwan Metthananda Nawarathne Nilesh Fernandopulle Than Than Aye Nwe Ni Sameer Al Awadhi Neeraj Joshi Pham Thi V. Ngoc Tuan V. Kieu Anh Duong Nguyen Murdani Abdullah Ezzat Ali Ahmed Zeid Jose D. Sollano Bismillah Saberi Mahmoud Omar Mostafa Noor Mohsin Hafeza Aftab Tin Moe Wai Yogesh M. Shastri Sujit Chaudhuri Faruque Ahmed Shobna J. Bhatia Simon P.L. Travis Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium |
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Background and Aim: Inflammatory bowel disease (IBD) is emerging in the newly industrialized countries of South Asia, South-East Asia, and the Middle East, yet epidemiological data are scarce. Methods: We performed a cross-sectional study of IBD demographics, disease phenotype, and treatment across 38 centers in 15 countries of South Asia, South-East Asia, and Middle East. Intergroup comparisons included gross national income (GNI) per capita. Results: Among 10 400 patients, ulcerative colitis (UC) was twice as common as Crohn's disease (CD), with a male predominance (UC 6678, CD 3495, IBD unclassified 227, and 58% male). Peak age of onset was in the third decade, with a low proportion of elderly-onset IBD (5% age > 60). Familial IBD was rare (5%). The extent of UC was predominantly distal (proctitis/left sided 67%), with most being treated with mesalamine (94%), steroids (54%), or immunomodulators (31%). Ileocolic CD (43%) was the commonest, with low rates of perianal disease (8%) and only 6% smokers. Diagnostic delay for CD was common (median 12 months; interquartile range 5–30). Treatment of CD included mesalamine, steroids, and immunomodulators (61%, 51%, and 56%, respectively), but a fifth received empirical antitubercular therapy. Treatment with biologics was uncommon (4% UC and 13% CD), which increased in countries with higher GNI per capita. Surgery rates were 0.1 (UC) and 2 (CD) per 100 patients per year. Conclusions: The IBD-ENC cohort provides insight into IBD in South-East Asia and the Middle East, but is not yet population based. UC is twice as common as CD, familial disease is uncommon, and rates of surgery are low. Biologic use correlates with per capita GNI. |
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Siriraj Hospital |
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Siriraj Hospital Rupa Banerjee Partha Pal Ida Hilmi Uday C. Ghoshal Devendra C. Desai Mohammed Masudur Rahman Usha Dutta Syed A. Mohiuddin Munnera Al Mohannadi Mathew Philip Ganesh N. Ramesh Madunil A. Niriella Arjuna P. De Silva Hithanadura Janaka de Silva Pises Pisespongsa Julajak Limsrivilai Satimai Aniwan Metthananda Nawarathne Nilesh Fernandopulle Than Than Aye Nwe Ni Sameer Al Awadhi Neeraj Joshi Pham Thi V. Ngoc Tuan V. Kieu Anh Duong Nguyen Murdani Abdullah Ezzat Ali Ahmed Zeid Jose D. Sollano Bismillah Saberi Mahmoud Omar Mostafa Noor Mohsin Hafeza Aftab Tin Moe Wai Yogesh M. Shastri Sujit Chaudhuri Faruque Ahmed Shobna J. Bhatia Simon P.L. Travis |
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Article |
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Rupa Banerjee Partha Pal Ida Hilmi Uday C. Ghoshal Devendra C. Desai Mohammed Masudur Rahman Usha Dutta Syed A. Mohiuddin Munnera Al Mohannadi Mathew Philip Ganesh N. Ramesh Madunil A. Niriella Arjuna P. De Silva Hithanadura Janaka de Silva Pises Pisespongsa Julajak Limsrivilai Satimai Aniwan Metthananda Nawarathne Nilesh Fernandopulle Than Than Aye Nwe Ni Sameer Al Awadhi Neeraj Joshi Pham Thi V. Ngoc Tuan V. Kieu Anh Duong Nguyen Murdani Abdullah Ezzat Ali Ahmed Zeid Jose D. Sollano Bismillah Saberi Mahmoud Omar Mostafa Noor Mohsin Hafeza Aftab Tin Moe Wai Yogesh M. Shastri Sujit Chaudhuri Faruque Ahmed Shobna J. Bhatia Simon P.L. Travis |
author_sort |
Rupa Banerjee |
title |
Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium |
title_short |
Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium |
title_full |
Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium |
title_fullStr |
Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium |
title_full_unstemmed |
Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium |
title_sort |
emerging inflammatory bowel disease demographics, phenotype, and treatment in south asia, south-east asia, and middle east: preliminary findings from the inflammatory bowel disease-emerging nations' consortium |
publishDate |
2022 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/74457 |
_version_ |
1763491077902303232 |