Efficacy of a Dengue Vaccine Candidate (TAK-003) in Healthy Children and Adolescents 2 Years after Vaccination

• Main Authors: Eduardo López-Medina, Shibadas Biswal, Xavier Saez-Llorens, Charissa Borja-Tabora, Lulu Bravo, Chukiat Sirivichayakul, Luis Martinez Vargas, Maria Theresa Alera, Hector Velásquez, Humberto Reynales, Luis Rivera, Veerachai Watanaveeradej, Edith Johana Rodriguez-Arenales, Delia Yu, Felix Espinoza, Reynaldo Dietze, Lak Kumar Fernando, Pujitha Wickramasinghe, Edson Duarte Moreira, Asvini D. Fernando, Dulanie Gunasekera, Kleber Luz, Rivaldo Venâncio Da Cunha, Vianney Tricou, Martina Rauscher, Mengya Liu, Inge Lefevre, Derek Wallace, Pope Kosalaraksa, Astrid Borkowski
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/74603
• Institution: Mahidol University

Background: Takeda's dengue vaccine is under evaluation in an ongoing phase 3 efficacy study; we present a 2-year update. Methods: Children (20 099, 4-16 years old) were randomized to receive 2 doses of TAK-003 or placebo 3 months apart and are under surveillance to detect dengue by serotype-sp...