Development and validation of an ultra-high performance liquid chromatography photodiode array method for the quantification of donepezil in human plasma and its application

• Main Authors: Rasda Boonprasert, Tippanate Keawvijit, Supawadee Pakdeenukoolkijja
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75051
• Institution: Mahidol University

An ultra-high performance liquid chromatography-photodiode array detection (UHPLC-PDA) method was developed and validated for determination of the concentration of donepezil in patient’s plasma. Plasma spiked with diphenhydramine as an internal standard was used for the solid phase extraction. The e...