Proteomic profiling reveals antitumor effects of RT2 peptide on a human colon carcinoma xenograft mouse model

• Main Authors: Surachai Maijaroen, Sompong Klaynongsruang, Somrudee Reabroi, Arthit Chairoungdua, Sittiruk Roytrakul, Jureerut Daduang, Lapatrada Taemaitree, Nisachon Jangpromma
• Other Authors: Khon Kaen University
• Format: Article
• Published: 2022
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75250
• Institution: Mahidol University

A comparative study of human colon HCT-116 xenograft in nude mice treated with and without peptide RT2 at high doses is performed along with a label-free proteomic analysis of the tissue in order to understand the potential mechanisms by which RT2 acts in vivo against colorectal tumors. RT2 displays...