Cyanidin-3-rutinoside stimulated insulin secretion through activation of L-type voltage-dependent Ca²⁺ channels and the PLC-IP<inf>3</inf> pathway in pancreatic β-cells

• Main Authors: Phutthida Kongthitilerd, Thavaree Thilavech, Marisa Marnpae, Weiqiong Rong, Shaomian Yao, Sirichai Adisakwattana, Henrique Cheng, Tanyawan Suantawee
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2022
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75253
• Institution: Mahidol University

Cyanidin-3-rutinoside (C3R) is an anthocyanin with anti-diabetic properties found in red-purple fruits. However, the molecular mechanisms of C3R on Ca2+-dependent insulin secretion remains unknown. This study aimed to identify C3R's mechanisms of action in pancreatic β-cells. Rat INS-1 cells we...