Interferon-γ signal drives differentiation of T-bet^hi atypical memory B cells into plasma cells following Plasmodium vivax infection

• Main Authors: Piyawan Kochayoo, Pongsakorn Thawornpan, Kittikorn Wangriatisak, Siriruk Changrob, Chaniya Leepiyasakulchai, Ladawan Khowawisetsut, John H. Adams, Patchanee Chootong
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75417
• Institution: Mahidol University

For development of a long-lasting protective malaria vaccine, it is crucial to understand whether Plasmodium-induced memory B cells (MBCs) or plasma cells develop and stably contribute to protective immunity, or on the contrary the parasite suppresses antibody responses by inducing MBC dysfunction....