Inhibitory effects of Triphala on CYP isoforms in vitro and its pharmacokinetic interactions with phenacetin and midazolam in rats

• Main Authors: Jannarin Nontakham, Pongpun Siripong, Hitoshi Sato, Savita Chewchinda, Kuntarat Arunrungvichian, Jantana Yahuafai, Arman Syah Goli, Vilasinee Hirunpanich Sato
• Other Authors: National Cancer Institute Thailand
• Format: Article
• Published: 2022
• Subjects: Multidisciplinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75443
• Institution: Mahidol University

Context: Direct evidence of Triphala-drug interactions has not been provided to date. Objective: This study was aimed to determine the effects of Triphala on cytochrome P450 (CYP) isoforms and P-glycoprotein (P-gp) in vitro, and to investigate pharmacokinetic interactions of Triphala with CYP-probes...