Antimicrobial, antimalarial, and cytotoxic substances from the insect pathogenic fungus Beauveria asiatica BCC 16812

• Main Authors: Jittra Kornsakulkarn, Thapanee Pruksatrakul, Panida Surawatanawong, Chattawat Thangsrikeattigun, Somjit Komwijit, Nattawut Boonyuen, Chawanee Thongpanchang
• Other Authors: Mahidol University
• Format: Article
• Published: 2022
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75664

Six new compounds 1–6 and two new naturally occurring compounds 7 and 8, together with nine known compounds 9–14, beauverioride I, dipicolinic acid, and 6-(methoxycarbonyl) picolinic acid were isolated from a wasp-pathogenic fungus Beauveria asiatica, strain BCC 16812. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compound 6 were established by the application of modified Mosher's method and ECD calculation. Compounds 9–11 exhibited antimalarial (IC50 0.47–1.79 u g/mL), antimicrobial (MIC 3.13–50.0 u g/mL), and cytotoxic (IC50 0.26–1.23 u g/mL) activities, while compounds 1, 2, 8, and 14 showed only cytotoxicity against Vero cell lines, with IC50 values range 12.96–47.03 u g/mL.