The hypoferremic response to acute inflammation is maintained in thalassemia mice even under parenteral iron loading

• Main Authors: Chanita Sanyear, Buraporn Chiawtada, Punnee Butthep, Saovaros Svasti, Suthat Fucharoen, Patarabutr Masaratana
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75681
• Institution: Mahidol University

Background: Hepcidin controls iron homeostasis by inducing the degradation of the iron efflux protein, ferroportin (FPN1), and subsequently reducing serum iron levels. Hepcidin expression is influenced by multiple factors, including iron stores, ineffective erythropoiesis, and inflammation. However,...