Hexane extract of seaweed caulerpa lentillifera inhibits cell proliferation and induces apoptosis of human glioblastoma cells

Hexane extract of seaweed caulerpa lentillifera inhibits cell proliferation and induces apoptosis of human glioblastoma cells

Glioblastoma is one the most aggressive types of brain cancers resistant to conventional anti-neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing va...

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Bibliographic Details
Main Authors: Varitta Tanawoot, Pornpun Vivithanaporn, Tanapan Siangcham, Krai Meemon, Nakorn Niamnont, Prasert Sobhon, Montakan Tamtin, Kant Sangpairoj
Other Authors: Faculty of Medicine Ramathibodi Hospital, Mahidol University
Format: Article
Published: 2022
Subjects:
Agricultural and Biological Sciences
Mathematics
Multidisciplinary
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/75687
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Institution: Mahidol University
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Summary:Glioblastoma is one the most aggressive types of brain cancers resistant to conventional anti-neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing various minerals and bioactive ingredients. This study demonstrated the activity of C. lentillifera hexane extract (CLHE) against A172 human glioblastoma cells. The extract exerted growth-inhibitory effects by inhibiting cell proliferation and inducing apoptosis. CLHE also induced ROS accumulation and altered mitochondrial membrane potential in A172 cells. Taken together, CLHE might be a potential anticancer agent for use against glioblastoma.

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