Cleistocalyx nervosum var. paniala seed extracts exhibit sigma-1 antagonist sensitive neuroprotective effects in PC12 cells and protects C. elegans from stress via the SKN-1/NRF-2 pathway

• Main Authors: James Michael Brimson, Mani Iyer Prasanth, Ciro Isidoro, Monruedee Sukprasansap, Tewin Tencomnao
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2022
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; Nursing
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75779
• Institution: Mahidol University

BACKGROUND: Cleistocalyx nervosum var. paniala (C. nervosum) is a plant that produces berries that are popular as a health food in Thailand. In previous studies we have identified C. nervosum fruit extracts to have anti-aging and anti-stress properties in C.elegans OBJECTIVE: Evaluate the neuroprote...