Synthesis of Isocryptolepine-Triazole Adducts and Evaluation of Their Cytotoxic Activity

Synthesis of Isocryptolepine-Triazole Adducts and Evaluation of Their Cytotoxic Activity

Eighteen hybrid compounds between 8-bromo-2-fluoro-isocryptolepine (4) and 1,2,3-triazole were synthesized via azide rearrangement-annulation reaction. Compound 4 underwent regioselective N-propargylation and click reaction to form 8-bromo-2-fluoro-isocryptolepine-triazole hybrids 11 which were eval...

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Main Authors: Warabhorn Rodphon, Pavitra Laohapaisan, Nantamon Supantanapong, Onrapak Reamtong, Lukana Ngiwsara, Kriengsak Lirdprapamongkol, Charnsak Thongsornkleeb, Nisachon Khunnawutmanotham, Jumreang Tummatorn, Jisnuson Svasti, Somsak Ruchirawat
Other Authors: Chulabhorn Research Institute
Format: Article
Published: 2022
Subjects:
Biochemistry, Genetics and Molecular Biology
Chemistry
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/75885
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/75885

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