Capturing tumour heterogeneity in pre- And post-chemotherapy colorectal cancer ascites-derived cells using single-cell RNA-sequencing

• Main Authors: Tiraput Poonpanichakul, Meng Shin Shiao, Natnicha Jiravejchakul, Ponpan Matangkasombut, Ekaphop Sirachainan, Varodom Charoensawan, Natini Jinawath
• Other Authors: Faculty of Medicine Ramathibodi Hospital, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75895
• Institution: Mahidol University

Malignant ascites is an abnormal accumulation of fluid within the peritoneal cavity, caused by metastasis of several types of cancers, including colorectal cancer (CRC). Cancer cells in ascites reflect poor prognosis and serve as a good specimen to study tumour heterogeneity, as they represent a col...